Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SORD | Q00796 | 2/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.33 |
| ▸ | HTR3B | O95264 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.33 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3406103 | 0.82 | KMT2A (0.54) | KMT2ACYP1A2CYP2D6MAPTUSP2 | |
| SCHEMBL3413188 | 0.81 | KMT2A (0.53) | KMT2ACYP1A2CYP2D6MAPTUSP2 | |
| SCHEMBL17893818 | 0.79 | PIM1 (0.40) | KMT2ACYP1A2CYP2D6MAPTLMNA | |
| SCHEMBL15956636 | 0.79 | HTR3A (0.53) | KMT2AHRH4HTR3EHTR3BHTR3A | |
| SCHEMBL30353341 | 0.78 | CYP1A2 (0.66) | KMT2ACYP1A2CYP2D6MAPTPOLB | |
| SCHEMBL20905447 | 0.78 | KMT2A (0.51) | KMT2ACYP1A2CYP2D6MAPTCHRM4 | |
| SCHEMBL913131 | 0.78 | CYP1A2 (0.66) | KMT2ACYP1A2CYP2D6MAPTPOLB | |
| Hydrochloric Acid SCHEMBL1854981 | 0.77 | KMT2A (0.50) | KMT2ACYP1A2CYP2D6MAPTCHRM4 | |
| SCHEMBL11963431 | 0.76 | GBA1 (0.42) | KMT2ACYP1A2CYP2D6MAPTLMNA | |
| SCHEMBL5429458 | 0.75 | LMNA (0.46) | CYP17A1KMT2ACYP1A2CYP2D6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6335341-B1 | ANTICHOLESTEROL AGENTS; ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2002-01-01 | — | — | US | disclosed |
| EP-1000057-A1 | PYRIDYL- AND PYRIMIDYL-HETEROCYCLIC COMPOUNDS INHIBITING OXIDO SQUALENE-CYCLASE | AstraZeneca UK Limited (GB) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999006395-A1 | PYRIDYL- AND PYRIMIDYL-HETEROCYCLIC COMPOUNDS INHIBITING OXIDO SQUALENE-CYCLASE | ZENECA LIMITED (GB) | 1999-02-11 | — | — | WO | disclosed |