Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 3/20 | 0.43 |
| ▸ | MMP9 | P14780 | 3/20 | 0.43 |
| ▸ | CA1 | P00915 | 7/20 | 0.41 |
| ▸ | CA2 | P00918 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.40 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP7 | P09237 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 4/20 | 0.38 |
| ▸ | CA9 | Q16790 | 4/20 | 0.38 |
| ▸ | BCL2 | P10415 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6565740 | 0.86 | ALDH1A1 (0.55) | CA1CA2ALDH1A1TSHRBCL2 | |
| SCHEMBL6564213 | 0.84 | CXCR1 (0.42) | CA1CA2ALDH1A1CXCR1CXCR2 | |
| SCHEMBL25352953 | 0.82 | MMP2 (0.50) | MMP2MMP9CA1CA2ALDH1A1 | |
| SCHEMBL25352949 | 0.82 | MMP2 (0.50) | MMP2MMP9CA1CA2ALDH1A1 | |
| SCHEMBL6563381 | 0.81 | MAPK1 (0.43) | CA1CA2ALDH1A1CXCR1CXCR2 | |
| SCHEMBL31685703 | 0.80 | MMP2 (0.54) | MMP2MMP9CA1CA2ALDH1A1 | |
| SCHEMBL25354045 | 0.79 | MMP2 (0.46) | MMP2MMP9CA1CA2ALDH1A1 | |
| SCHEMBL25354041 | 0.79 | MMP2 (0.46) | MMP2MMP9CA1CA2ALDH1A1 | |
| SCHEMBL12287583 | 0.79 | MMP2 (0.46) | MMP2MMP9CA1CA2ALDH1A1 | |
| SCHEMBL29397920 | 0.76 | ALDH1A1 (0.63) | MMP2MMP9CA1CA2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6500863-B1 | INTERLEUKIN BINDING INHIBITORS SUCH AS N-(2-HYDROXYL-3-AMINO SULFONYL-4-CHLOROPHENYL)-N'-(2-BROMOPHENYL)UREA, USED FOR PROPHYLAXIS OF CHEMOKINE MEDIATED DISEASES | SMITHKLINE BEECHAM CORPORATION | 2002-12-31 | — | — | US | disclosed |