Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 6/20 | 0.57 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7667964 | 1.00 | ADRA1A (0.57) | ADRA1AADRA1DADRA1BMEN1KMT2A | |
| SCHEMBL7667781 | 1.00 | ADRA1A (0.57) | ADRA1AADRA1DADRA1BMEN1KMT2A | |
| SCHEMBL10113415 | 0.86 | TP53 (0.70) | ADRA1AADRA1DADRA1BMEN1KMT2A | |
| SCHEMBL7661429 | 0.80 | ADRA1A (0.45) | ADRA1AADRA1DADRA1BMEN1KMT2A | |
| SCHEMBL7655667 | 0.80 | ADRA1A (0.45) | ADRA1AADRA1DADRA1BMEN1KMT2A | |
| SCHEMBL6348283 | 0.80 | MEN1 (0.55) | MEN1KMT2ATP53GAAL3MBTL1 | |
| SCHEMBL7930709 | 0.77 | ADRA1A (0.55) | ADRA1AADRA1DADRA1BKMT2ALMNA | |
| SCHEMBL7930713 | 0.77 | ADRA1A (0.55) | ADRA1AADRA1DADRA1BKMT2ALMNA | |
| SCHEMBL2570938 | 0.77 | USP2 (0.52) | TP53GAAL3MBTL1 | |
| SCHEMBL7660049 | 0.77 | USP2 (0.52) | TP53GAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6339090-B1 | FOR THERAPY OF BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC. | 2002-01-15 | — | — | US | claimed |
| WO-2000006565-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2000-02-10 | — | — | WO | claimed |
| US-6339090-B1 | FOR THERAPY OF BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC. | 2002-01-15 | — | — | US | disclosed |
| WO-2000006565-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2000-02-10 | — | — | WO | disclosed |