Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 10/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 6/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 6/20 | 0.55 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 5/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.49 |
| ▸ | HRH1 | P35367 | 5/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7930709 | 1.00 | ADRA1A (0.55) | ADRA1AADRA1DADRA1BGPBAR1ADRA2A | |
| SCHEMBL3897173 | 0.82 | GPBAR1 (0.74) | GPBAR1TSHRKMT2ANPSR1 | |
| SCHEMBL3888065 | 0.79 | GPBAR1 (0.52) | ADRA1AADRA1DADRA1BGPBAR1TSHR | |
| SCHEMBL13698259 | 0.79 | CYP19A1 (0.59) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL3886406 | 0.79 | GPBAR1 (0.49) | ADRA1AADRA1DADRA1BGPBAR1ADRA2A | |
| SCHEMBL7667781 | 0.77 | ADRA1A (0.57) | ADRA1AADRA1DADRA1BKMT2ALMNA | |
| SCHEMBL7667964 | 0.77 | ADRA1A (0.57) | ADRA1AADRA1DADRA1BKMT2ALMNA | |
| SCHEMBL7656196 | 0.77 | ADRA1A (0.57) | ADRA1AADRA1DADRA1BKMT2ALMNA | |
| SCHEMBL7660010 | 0.75 | ADRA1A (0.53) | ADRA1AADRA1DADRA1BHTR7TSHR | |
| SCHEMBL7664087 | 0.75 | ADRA1A (0.53) | ADRA1AADRA1DADRA1BHTR7TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000025782-A1 | DIHYDROPYRIDINONES AND PYRROLINONES USEFUL AS ALPHA 1A ADRENOCEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2000-05-11 | — | — | WO | claimed |
| US-6235759-B1 | BENIGN PROSTATIC HYPERPLASIA; HYPOTENSIVE AGENTS | MERCK & CO., INC. | 2001-05-22 | — | — | US | disclosed |
| WO-2000025782-A1 | DIHYDROPYRIDINONES AND PYRROLINONES USEFUL AS ALPHA 1A ADRENOCEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2000-05-11 | — | — | WO | disclosed |