Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | DRD2 | P14416 | 6/20 | 0.57 |
| ▸ | HTR1A | P08908 | 5/20 | 0.57 |
| ▸ | DRD3 | P35462 | 5/20 | 0.57 |
| ▸ | HTR2A | P28223 | 4/20 | 0.57 |
| ▸ | DRD1 | P21728 | 3/20 | 0.57 |
| ▸ | DRD5 | P21918 | 2/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4447104 | 0.96 | DRD2 (0.58) | CYP2D6DRD2HTR1ADRD3HTR2A | |
| SCHEMBL1307809 | 0.91 | POLB (0.53) | DRD2HTR1ADRD3HTR2ADRD1 | |
| SCHEMBL26108581 | 0.89 | HTR1A (0.65) | CYP2D6DRD2HTR1ADRD3HTR2A | |
| SCHEMBL26492991 | 0.89 | HTR1A (0.65) | CYP2D6DRD2HTR1ADRD3HTR2A | |
| Hydrochloric Acid SCHEMBL26108377 | 0.87 | DRD2 (0.63) | DRD2HTR1ADRD3HTR2ADRD1 | |
| SCHEMBL1254644 | 0.85 | HTR1A (0.57) | DRD2HTR1ADRD3HTR2ADRD1 | |
| SCHEMBL15383634 | 0.85 | DRD2 (0.48) | CYP2D6DRD2HTR1ADRD3HTR2A | |
| SCHEMBL9260064 | 0.84 | HTR1A (0.60) | CYP2D6DRD2HTR1ADRD3HTR2A | |
| SCHEMBL9286378 | 0.84 | LMNA (0.59) | DRD2HTR1ADRD3HTR2ADRD1 | |
| SCHEMBL10532680 | 0.84 | HTR1A (0.56) | DRD2HTR1ADRD3HTR2ADRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6462047-B1 | CONTAINING 5- OR 6-MEMBERED OXYGEN, NITROGEN AND/OR SULFUR HETEROARYL GROUP; ANGINA, HYPERTENSION, RESPIRATORY DISTRESS, CONGESTIVE HEART FAILURE, RENAL FAILURE, ATHEROSCLEROSIS, INFLAMMATORY DISEASES, STROKES, BRONCHITIS, ASTHMA | ICOS CORPORATION | 2002-10-08 | — | — | US | disclosed |
| US-6432946-B1 | PSYCHOLOGICAL DISORDERS; CENTRAL NERVOUS SYSTEM DISORDERS | NEUROGEN CORPORATION | 2002-08-13 | — | — | US | disclosed |
| EP-1027347-A2 | 3-AMINOALKYLAMINO-2H-1,4-BENZOXA(THIA-)ZINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | NEUROGEN CORPORATION (US) | 2000-08-16 | — | — | EP | disclosed |
| US-6100255-A | BIND SELECTIVELY WITH HIGH AFFINITY TO THE DOPAMINE D4 RECEPTOR SUBTYPE; USE IN TREATING VARIOUS NEUROPSYCHOLOGICAL DISORDERS, INCLUDING ALZHEIMER'S DISEASE, SCHIZOPHRENIA, PARKINSON'S DISEASE, OR TARDIVE DYSKINESIA | NEUROGEN CORPORATION (US) | 2000-08-08 | — | — | US | disclosed |
| WO-1999023092-A2 | 3-AMINOALKYLAMINO-2H-1,4-BENZOXA(THIA-)ZINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | NEUROGEN CORPORATION (US) | 1999-05-14 | — | — | WO | disclosed |
| CN-1177957-A | Indole derivatives for the treatment of osteoporosis | SMITHKLINE BEECHAM SPA (IT) | 1998-04-01 | — | — | CN | disclosed |
| EP-0343961-B1 | Aryl- and heteroaryl piperazinyl carboxamides having central nervous system activity | AMERICAN HOME PROD (US) | 1996-01-10 | — | — | EP | disclosed |
| US-5482940-A | OBESITY, ALCOHOLISM | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-01-09 | — | — | US | disclosed |
| US-5380725-A | Antipsychotic agents and anxiolytic agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-01-10 | — | — | US | disclosed |
| US-5314884-A | Antidepressants, anxiolytic agents | TROPONWERKE GMBH & CO. (DE) | 1994-05-24 | — | — | US | disclosed |
| EP-0129128-B1 | 2-PYRIMIDINYL-1-PIPERAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM | Troponwerke GmbH & Co. KG (DE) | 1990-11-22 | — | — | EP | disclosed |
| US-4937343-A | NEUROLEPTICS OR ANTIDEPRESSANTS | TROPONWERKE GMBH & CO. KG (DE) | 1990-06-26 | — | — | US | disclosed |
| EP-0343961-A2 | Aryl- and heteroaryl piperazinyl carboxamides having central nervous system activity | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-11-29 | — | — | EP | disclosed |
| US-4882432-A | ANTIDEPRESSANT, ANTIPSYCHOTIC | AMERICAN HOME PRODUCTS CORPORATION (US) | 1989-11-21 | — | — | US | disclosed |
| US-4818756-A | CENTRAL NERVOUS SYSTEM DISORDERS | TROPONWERKE GMBH & CO., KG (DE) | 1989-04-04 | — | — | US | disclosed |
| EP-0082402-B1 | SUCCINIMIDE DERIVATES AND PROCESS FOR PREPARATION THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1986-04-02 | — | — | EP | disclosed |
| US-4543355-A | Substituted succinimides, compositions and method of use | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1985-09-24 | — | — | US | disclosed |
| US-4507303-A | Succinimide derivatives, compositions and method of use | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1985-03-26 | — | — | US | disclosed |
| EP-0129128-A2 | 2-Pyrimidinyl-1-piperazine derivatives, process for their preparation and medicines containing them | Troponwerke GmbH & Co. KG (DE) | 1984-12-27 | — | — | EP | disclosed |
| EP-0082402-A2 | Succinimide derivates and process for preparation thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1983-06-29 | — | — | EP | disclosed |