Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | CTSA | P10619 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7650887 | 0.84 | CNR1 (0.39) | CTSA | |
| SCHEMBL7658839 | 0.80 | CNR1 (0.40) | CNR2LMNA | |
| SCHEMBL7107812 | 0.78 | POLB (0.47) | P2RX7CNR2POLBLMNACTSA | |
| SCHEMBL7663610 | 0.75 | P2RX7 (0.44) | P2RX7POLBLMNACTSAKDM4E | |
| SCHEMBL18157898 | 0.75 | MEN1 (0.56) | P2RX7ALDH1A1L3MBTL1POLBLMNA | |
| SCHEMBL7663622 | 0.74 | POLB (0.41) | P2RX7CNR2POLBLMNACTSA | |
| SCHEMBL7659871 | 0.73 | LMNA (0.45) | P2RX7ALDH1A1CNR2POLBLMNA | |
| SCHEMBL3105049 | 0.71 | KDM4E (0.61) | ALDH1A1POLBLMNAKDM4EMEN1 | |
| SCHEMBL20729958 | 0.71 | BRD4 (0.55) | ALDH1A1L3MBTL1CNR2POLBBRD4 | |
| SCHEMBL24742673 | 0.71 | LMNA (0.46) | P2RX7ALDH1A1L3MBTL1CNR2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |