Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PAOX | Q6QHF9 | 2/20 | 0.38 |
| ▸ | NAAA | Q02083 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10811442 | 0.85 | — | — | |
| SCHEMBL4170837 | 0.82 | POLB (0.41) | POLBHPGDPKMMEN1HTT | |
| SCHEMBL4170832 | 0.82 | S1PR5 (0.43) | POLBHPGDPKMMEN1KMT2A | |
| SCHEMBL14321921 | 0.82 | POLB (0.39) | POLBHPGDPKMMEN1HTT | |
| SCHEMBL6565536 | 0.81 | CYP1A2 (0.48) | HPGDNAAACYP1A2 | |
| SCHEMBL9668398 | 0.79 | CYP1A2 (0.52) | HPGDNAAACYP1A2 | |
| SCHEMBL8023937 | 0.77 | KDM5A (0.49) | MEN1HTTKMT2APAOXNAAA | |
| SCHEMBL9978410 | 0.77 | KDM5A (0.49) | MEN1HTTKMT2APAOXNAAA | |
| SCHEMBL12513177 | 0.77 | KDM5A (0.49) | MEN1HTTKMT2APAOXNAAA | |
| SCHEMBL4171456 | 0.77 | L3MBTL1 (0.51) | POLBHPGDPKMMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2288598-B1 | THIOPHENE DERIVATIVES USEFUL AS OCULAR HYPOTENSIVE AGENTS | ALLERGAN INC (US) | 2012-03-21 | — | — | EP | disclosed |