Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | DGAT1 | O75907 | 7/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | ESR1 | P03372 | 1/20 | 0.55 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.55 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.55 |
| ▸ | STAT3 | P40763 | 1/20 | 0.55 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.54 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1594391 | 0.89 | KMT2A (0.66) | RAB9ACYP1A2NPC1SMN1; SMN2DGAT1 | |
| SCHEMBL1593432 | 0.88 | KMT2A (0.64) | RAB9ACYP1A2NPC1SMN1; SMN2DGAT1 | |
| SCHEMBL1593512 | 0.83 | KMT2A (0.58) | NPC1SMN1; SMN2DGAT1MAPTKMT2A | |
| SCHEMBL21379546 | 0.82 | MAPT (0.70) | RAB9ACYP1A2NPC1SMN1; SMN2LMNA | |
| SCHEMBL2169030 | 0.81 | MAPT (0.78) | RAB9ACYP1A2NPC1SMN1; SMN2LMNA | |
| SCHEMBL896528 | 0.79 | RAB9A (0.60) | RAB9ACYP1A2NPC1SMN1; SMN2LMNA | |
| SCHEMBL29739339 | 0.79 | RAB9A (0.60) | RAB9ACYP1A2NPC1SMN1; SMN2LMNA | |
| SCHEMBL12392903 | 0.78 | MAPT (0.65) | RAB9ACYP1A2NPC1SMN1; SMN2LMNA | |
| SCHEMBL50482 | 0.78 | MAPT (0.69) | RAB9ACYP1A2NPC1SMN1; SMN2LMNA | |
| SCHEMBL8139126 | 0.78 | ALDH1A1 (0.49) | RAB9ACYP1A2NPC1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407120-B1 | ADMINISTERING PYRIDINYLACETAMIDE OR PHENYLACETAMIDE DERIVATIVE TO TREAT CARDIOVASCULAR, EATING, SEXUAL, BRAIN, NERVOUS SYSTEM, GASTROINTESTINAL, UROGENITAL, PSYCHOLOGICAL, AND RESPIRATORY SYSTEM DISORDERS | PFIZER INC. | 2002-06-18 | — | — | US | disclosed |