Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 16/20 | 0.54 |
| ▸ | TOP2A | P11388 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8084873 | 0.89 | ALOX5 (0.64) | ALOX5TOP2A | |
| SCHEMBL7655746 | 0.88 | ALOX5 (0.54) | ALOX5TOP2AKDM4EGLA | |
| SCHEMBL8080529 | 0.88 | ALOX5 (0.54) | ALOX5TOP2AKDM4E | |
| Helioxanthin SCHEMBL29623971 | 0.88 | ALOX5 (0.70) | ALOX5TOP2AKDM4E | |
| Helioxanthin SCHEMBL2960321 | 0.88 | ALOX5 (0.70) | ALOX5TOP2AKDM4E | |
| SCHEMBL7654491 | 0.86 | ALOX5 (0.61) | ALOX5TOP2A | |
| SCHEMBL8082006 | 0.85 | ALOX5 (0.51) | ALOX5TOP2A | |
| SCHEMBL7656265 | 0.85 | ALOX5 (0.60) | ALOX5TOP2AKDM4E | |
| SCHEMBL8084991 | 0.81 | TOP2A (0.70) | ALOX5TOP2AKDM4E | |
| SCHEMBL8082187 | 0.79 | PDE1A (0.60) | ALOX5TOP2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6340704-B1 | TREATING NERVE DISEASE OR BONE/JOINT DISEASE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-01-22 | — | — | US | disclosed |
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |
| EP-0975621-A1 | CELL DIFFERENTIATION INDUCING AMIDE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998049155-A1 | CELL DIFFERENTIATION INDUCING AMIDE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-11-05 | — | — | WO | disclosed |