Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 13/20 | 0.51 |
| ▸ | TOP2A | P11388 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ESRRB | O95718 | 1/20 | 0.37 |
| ▸ | ESRRA | P11474 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7655746 | 0.88 | ALOX5 (0.54) | ALOX5TOP2AMEN1KMT2A | |
| SCHEMBL8084873 | 0.86 | ALOX5 (0.64) | ALOX5TOP2A | |
| SCHEMBL7656932 | 0.85 | ALOX5 (0.54) | ALOX5TOP2A | |
| SCHEMBL8080529 | 0.85 | ALOX5 (0.54) | ALOX5TOP2AMEN1ALDH1A1KMT2A | |
| Helioxanthin SCHEMBL29623971 | 0.85 | ALOX5 (0.70) | ALOX5TOP2AMEN1ALDH1A1KMT2A | |
| Helioxanthin SCHEMBL2960321 | 0.85 | ALOX5 (0.70) | ALOX5TOP2AMEN1ALDH1A1KMT2A | |
| SCHEMBL7654491 | 0.83 | ALOX5 (0.61) | ALOX5TOP2A | |
| SCHEMBL8080428 | 0.83 | ALOX5 (0.53) | ALOX5MEN1ALDH1A1KMT2AESRRB | |
| SCHEMBL7656265 | 0.83 | ALOX5 (0.60) | ALOX5TOP2AMEN1ALDH1A1KMT2A | |
| SCHEMBL8081605 | 0.81 | PARP1 (0.48) | ALOX5MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6030967-A | AND/OR LIKE NEUROTROPHIC FACTOR (FOR EXAMPLE, NERVE GROWTH FACTOR (NGF), BRAIN-DERIVED NEUROTROPHIC FACTOR, NEUROTROPHIN-3, AND GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR)-LIKE ACTIVITY; OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-02-29 | — | — | US | disclosed |