SCHEMBL7656943

SCHEMBL7656943

CC(C)C#CC1(C(F)(F)F)OCC(=O)Nc2ccc(F)c(F)c21

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PGR P06401 18/20 0.39
HTR2A P28223 2/20 0.35
ADRA2C P18825 1/20 0.35
TACR2 P21452 1/20 0.35
ADRA1D P25100 1/20 0.35
PTH1R Q03431 1/20 0.35
NR1I2 O75469 1/20 0.32
NR3C1 P04150 1/20 0.32
ADRB1 P08588 1/20 0.32
ADORA3 P0DMS8 1/20 0.32
MAPT P10636 1/20 0.32
CNR1 P21554 1/20 0.32
SLC6A2 P23975 1/20 0.32
HTR2C P28335 1/20 0.32
MAPK1 P28482 1/20 0.32
AGTR1 P30556 1/20 0.32
CCKBR P32239 1/20 0.32
PPARG P37231 1/20 0.32
OPRK1 P41145 1/20 0.32
SLC6A3 Q01959 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6986545 0.82 CYP46A1 (0.44) PGRHTR2AADRA2CTACR2ADRA1D
SCHEMBL1152913 0.81 PGR (0.49) PGRHTR2ANR1I2NR3C1ADRB1
SCHEMBL1152420 0.81 PGR (0.49) PGRHTR2ANR1I2NR3C1ADRB1
SCHEMBL1152289 0.80 PGR (0.46) PGRHTR2ANR1I2NR3C1ADRB1
SCHEMBL7636124 0.73 ADRA2C (0.32) PGRHTR2AADRA2CTACR2ADRA1D
SCHEMBL1152243 0.73 ADRA2C (0.45) PGRHTR2AADRA2CTACR2ADRA1D
SCHEMBL1152246 0.73 ADRA2C (0.45) PGRHTR2AADRA2CTACR2ADRA1D
SCHEMBL7237856 0.71 ADRA2C (0.33) HTR2AADRA2CTACR2ADRA1DPTH1R
SCHEMBL7004996 0.69 CYP46A1 (0.40) PGRHTR2ANR1I2NR3C1ADRB1
SCHEMBL1152462 0.65 CYP46A1 (0.59) PGRHTR2ANR1I2NR3C1ADRB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6489320-B1 NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR AND BENZOXAPINONE FOR TREATMENT OF HIV INFECTION BRISTOL-MYERS SQUIBB PHARMA COMPANY 2002-12-03 US claimed
US-6489320-B1 NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR AND BENZOXAPINONE FOR TREATMENT OF HIV INFECTION BRISTOL-MYERS SQUIBB PHARMA COMPANY 2002-12-03 US disclosed
US-6140320-A FOR TREATING HIV(HUMAN IMMUNODEFICIENCY VIRUS) INFECTIONS DUPONT PHARMACEUTICALS COMPANY (US) 2000-10-31 US disclosed
EP-1009742-A1 5,5-DISUBSTITUTED-1,5-DIHYDRO-4,1-BENZOXAZEPIN-2(3H)-ONES USEFUL AS HIV REVERSE TRANSCRIPTASE INHIBITORS Du Pont Pharmaceuticals Company (US) 2000-06-21 EP disclosed
WO-1999011635-A1 5,5-DISUBSTITUTED-1,5-DIHYDRO-4,1-BENZOXAZEPIN-2(3H)-ONES USEFUL AS HIV REVERSE TRANSCRIPTASE INHIBITORS DU PONT PHARMACEUTICALS COMPANY (US) 1999-03-11 WO disclosed