Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL753573 | 0.84 | HDAC4 (0.41) | HDAC4HDAC7HDAC5KDM4ERPS6KB1 | |
| SCHEMBL14207676 | 0.84 | HDAC4 (0.38) | HDAC4HDAC7HDAC5KDM4ERPS6KB1 | |
| SCHEMBL10201034 | 0.78 | KCNQ2 (0.40) | HDAC4HDAC7HDAC5KDM4ESMN1; SMN2 | |
| SCHEMBL752315 | 0.76 | MAPT (0.40) | KDM4ELMNAALDH1A1GAASMN1; SMN2 | |
| SCHEMBL10331383 | 0.71 | HDAC4 (0.40) | HDAC4HDAC7HDAC5KDM4ELMNA | |
| SCHEMBL10331384 | 0.71 | HDAC4 (0.40) | HDAC4HDAC7HDAC5KDM4ELMNA | |
| SCHEMBL14207656 | 0.71 | HDAC4 (0.37) | HDAC4HDAC7HDAC5KDM4ECES2 | |
| SCHEMBL754423 | 0.71 | HDAC4 (0.40) | HDAC4HDAC7HDAC5KDM4ELMNA | |
| SCHEMBL10201035 | 0.66 | KCNQ2 (0.39) | SMN1; SMN2TSHROPRM1 | |
| SCHEMBL14826292 | 0.65 | KCNN4 (0.50) | ALDH1A1CYP2C9CYP2C19TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078015-B1 | MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1 AND/OR NF-KAPPAB ACTIVITY AND USE THEREOF | BRISTOL MYERS SQUIBB CO (US) | 2012-03-21 | — | — | EP | disclosed |