Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 2/20 | 0.61 |
| ▸ | CTSS | P25774 | 2/20 | 0.61 |
| ▸ | CTSB | P07858 | 1/20 | 0.61 |
| ▸ | CTSK | P43235 | 1/20 | 0.61 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8913074 | 0.84 | CTSL (0.69) | CTSLCTSSCTSBCTSKOPRK1 | |
| SCHEMBL13707667 | 0.81 | LMNA (0.56) | CTSLCTSSCTSBCTSKLMNA | |
| SCHEMBL764273 | 0.80 | CTSL (0.64) | CTSLCTSSCTSBCTSKOPRK1 | |
| SCHEMBL13257317 | 0.79 | CTSL (0.60) | CTSLCTSSCTSBCTSKOPRK1 | |
| SCHEMBL11288818 | 0.79 | LMNA (0.55) | CTSLCTSSCTSBCTSKLMNA | |
| SCHEMBL12358402 | 0.79 | CTSL (0.60) | CTSLCTSSCTSBCTSKOPRK1 | |
| SCHEMBL13256477 | 0.79 | CTSL (0.60) | CTSLCTSSCTSBCTSKOPRK1 | |
| SCHEMBL3361808 | 0.79 | LMNA (0.61) | CTSLCTSSCTSBCTSKLMNA | |
| SCHEMBL4462583 | 0.79 | LMNA (0.61) | CTSLCTSSCTSBCTSKLMNA | |
| SCHEMBL1722707 | 0.78 | CTSL (0.59) | CTSLCTSSCTSBCTSKOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492370-B1 | Urea derivatives and pharmaceutical compositions thereof | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2002-12-10 | — | — | US | disclosed |
| CN-1299344-A | Novel urea derivatives | SANTEN PHARCEUMATICAL CO LTD (JP) | 2001-06-13 | — | — | CN | disclosed |