Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | KLK7 | P49862 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | YAP1 | P46937 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4385892 | 0.93 | SMN1; SMN2 (0.42) | GPR119KLK7MEN1KMT2ANPSR1 | |
| SCHEMBL15110164 | 0.81 | MEN1 (0.51) | L3MBTL1GPR119MAPTMEN1KMT2A | |
| SCHEMBL23343000 | 0.79 | L3MBTL1 (0.44) | L3MBTL1GPR119KLK7MAPTMEN1 | |
| SCHEMBL25426557 | 0.77 | SMN1; SMN2 (0.45) | L3MBTL1MEN1KMT2APARP1STS | |
| SCHEMBL6894705 | 0.76 | HTT (0.52) | L3MBTL1GPR119MAPTMEN1KMT2A | |
| SCHEMBL6580060 | 0.74 | KCNA3 (0.47) | L3MBTL1MAPTMEN1KMT2AMAPK1 | |
| SCHEMBL17736 | 0.74 | MEN1 (0.49) | L3MBTL1MEN1KMT2AMAPK1NPSR1 | |
| SCHEMBL24326113 | 0.73 | MEN1 (0.51) | MEN1KMT2AMAPK1NPSR1PARP1 | |
| SCHEMBL23343010 | 0.73 | USP30 (0.48) | L3MBTL1GPR119KLK7MAPTMEN1 | |
| SCHEMBL23342998 | 0.73 | USP30 (0.48) | L3MBTL1GPR119KLK7MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6335341-B1 | ANTICHOLESTEROL AGENTS; ATHEROSCLEROSIS | ZENECA LIMITED (GB) | 2002-01-01 | — | — | US | disclosed |
| EP-1000057-A1 | PYRIDYL- AND PYRIMIDYL-HETEROCYCLIC COMPOUNDS INHIBITING OXIDO SQUALENE-CYCLASE | AstraZeneca UK Limited (GB) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999006395-A1 | PYRIDYL- AND PYRIMIDYL-HETEROCYCLIC COMPOUNDS INHIBITING OXIDO SQUALENE-CYCLASE | ZENECA LIMITED (GB) | 1999-02-11 | — | — | WO | disclosed |