Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.61 |
| ▸ | HTR2B | P41595 | 8/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | FLT4 | P35916 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.50 |
| ▸ | CDK8 | P49336 | 1/20 | 0.50 |
| ▸ | CLK2 | P49760 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7452301 | 0.81 | NPC1 (0.72) | HTR2CHTR2BNPC1MAPTRAB9A | |
| SCHEMBL27579461 | 0.78 | PLK4 (0.73) | HTR2CHTR2BPLK4CHEK1PDPK1 | |
| SCHEMBL22803696 | 0.78 | NPC1 (0.67) | NPC1MAPTRAB9APRKCIEPHX1 | |
| SCHEMBL6166855 | 0.77 | MAOA (0.73) | NPC1MAPTRAB9ACFTREPHX1 | |
| SCHEMBL3807061 | 0.77 | HTR2C (0.73) | HTR2CHTR2BMAPTPLK4CHEK1 | |
| SCHEMBL7369475 | 0.77 | HTR2C (0.75) | HTR2CHTR2BNPC1MAPTRAB9A | |
| SCHEMBL31668688 | 0.77 | MAOA (0.66) | NPC1MAPTRAB9APRKCIEPHX1 | |
| Hydrochloric Acid SCHEMBL7652837 | 0.76 | HTR2C (0.60) | HTR2CHTR2BNPC1MAPTPLK4 | |
| Hydrochloric Acid SCHEMBL7448902 | 0.76 | HTR2C (0.61) | HTR2CHTR2BNPC1MAPTRAB9A | |
| SCHEMBL31668675 | 0.76 | NPC1 (0.64) | NPC1MAPTRAB9APRKCIEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6410529-B1 | DIETETICS; NON-INSULIN DEPENDENT DIABETES; SLEEP DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-06-25 | — | — | US | claimed |
| US-6410529-B1 | DIETETICS; NON-INSULIN DEPENDENT DIABETES; SLEEP DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-06-25 | — | — | US | disclosed |