Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RAD52 | P43351 | 1/20 | 0.30 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12005468 | 0.83 | NR1H2 (0.35) | LMNAADRA2CNR1H2KDM4EMAPT | |
| SCHEMBL1952271 | 0.83 | LMNA (0.33) | LMNAADRA2CNR1H2KDM4EMAPT | |
| SCHEMBL24478558 | 0.83 | SLC6A2 (0.34) | OPRM1KDM4EBACE1 | |
| SCHEMBL12005557 | 0.81 | WEE1 (0.38) | LMNANR1H2KDM4EMAPTRAD52 | |
| SCHEMBL16370737 | 0.81 | NR1H2 (0.37) | LMNAADRA2CNR1H2 | |
| SCHEMBL28813979 | 0.81 | HSD17B3 (0.35) | NR1H2 | |
| SCHEMBL29506598 | 0.79 | ADRA2C (0.39) | LMNAADRA2CNR1H2KDM4EMAPT | |
| SCHEMBL1952621 | 0.79 | ADRA2C (0.39) | LMNAADRA2CNR1H2KDM4EMAPT | |
| SCHEMBL12005043 | 0.78 | NR1H2 (0.37) | LMNAADRA2CNR1H2OPRM1BACE1 | |
| SCHEMBL31057815 | 0.77 | CHKA (0.39) | HDAC2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492378-B1 | Substituted isoquinoline derivatives and their use as anticonvulsivants | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-12-10 | — | — | US | disclosed |
| EP-1104404-A1 | SUBSTITUTED ISOQUINOLINE DERIVATIVES AND THEIR USE AS ANTICONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 2001-06-06 | — | — | EP | disclosed |
| WO-2000009486-A1 | SUBSTITUTED ISOQUINOLINE DERIVATIVES AND THEIR USE AS ANTICONVULSIVANTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-02-24 | — | — | WO | disclosed |