Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 2/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.43 |
| ▸ | TNKS | O95271 | 1/20 | 0.43 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.43 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.43 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.39 |
| ▸ | SIRT3 | Q9NTG7 | 3/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GPR132 | Q9UNW8 | 2/20 | 0.38 |
| ▸ | VNN1 | O95497 | 2/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.37 |
| ▸ | LOX | P28300 | 3/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL765832 | 0.92 | BDKRB1 (0.54) | BDKRB1PARP10TNKSPARP15PARP14 | |
| SCHEMBL12239071 | 0.88 | BDKRB1 (0.53) | BDKRB1PARP10TNKSPARP15PARP14 | |
| SCHEMBL764455 | 0.82 | BDKRB1 (0.57) | BDKRB1PARP10PARP15PARP14MAPK14 | |
| SCHEMBL10121171 | 0.81 | BDKRB1 (0.46) | BDKRB1MAPK14CYP3A4 | |
| SCHEMBL12239066 | 0.81 | BDKRB1 (0.49) | BDKRB1MAPK14LMNACYP3A4HTT | |
| SCHEMBL765624 | 0.80 | MAPK14 (0.53) | BDKRB1MAPK14LMNACYP3A4HTT | |
| SCHEMBL10121225 | 0.80 | BDKRB1 (0.58) | BDKRB1MAPK14LMNACYP3A4HTT | |
| SCHEMBL10121359 | 0.80 | BDKRB1 (0.55) | BDKRB1MAPK14LMNACYP3A4HTT | |
| SCHEMBL764413 | 0.80 | BDKRB1 (0.64) | BDKRB1MAPK14LMNACYP3A4HTT | |
| SCHEMBL765176 | 0.79 | BDKRB1 (0.51) | BDKRB1PARP10PARP14LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188254-B1 | NOVEL BRADYKININ B1-ANTAGONISTS | BOEHRINGER INGELHEIM INT (DE) | 2012-03-21 | — | — | EP | disclosed |