Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.53 |
| ▸ | BDKRB1 | P46663 | 4/20 | 0.51 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.38 |
| ▸ | LPAR5 | Q9H1C0 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | MMP13 | P45452 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.36 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL764461 | 0.92 | BDKRB1 (0.61) | MAPK14BDKRB1EZH2LPAR1LPAR5 | |
| SCHEMBL765612 | 0.88 | BDKRB1 (0.45) | MAPK14BDKRB1CYP3A4HTTSMN1; SMN2 | |
| SCHEMBL10121101 | 0.86 | BDKRB1 (0.45) | MAPK14BDKRB1CYP3A4HTTSMN1; SMN2 | |
| SCHEMBL764458 | 0.82 | BDKRB1 (0.64) | MAPK14BDKRB1EZH2CYP3A4LMNA | |
| SCHEMBL10121331 | 0.81 | BDKRB1 (0.60) | MAPK14BDKRB1CYP3A4MMP13HTT | |
| SCHEMBL764501 | 0.81 | BDKRB1 (0.49) | MAPK14BDKRB1CYP3A4LMNA | |
| SCHEMBL10121385 | 0.81 | BDKRB1 (0.53) | MAPK14BDKRB1CYP3A4CARM1PRMT6 | |
| SCHEMBL12239067 | 0.81 | BDKRB1 (0.60) | MAPK14BDKRB1CYP3A4MMP13HTT | |
| SCHEMBL12239078 | 0.80 | BDKRB1 (0.54) | MAPK14BDKRB1CYP3A4MMP13HTT | |
| SCHEMBL765172 | 0.80 | BDKRB1 (0.58) | MAPK14BDKRB1CYP3A4MMP13HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188254-B1 | NOVEL BRADYKININ B1-ANTAGONISTS | BOEHRINGER INGELHEIM INT (DE) | 2012-03-21 | — | — | EP | disclosed |