Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 2/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.37 |
| ▸ | CCR2 | P41597 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | USP36 | Q9P275 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL764448 | 0.92 | BDKRB1 (0.53) | BDKRB1MAPK14SCN9AKDM1AHDAC1 | |
| SCHEMBL12239075 | 0.88 | BDKRB1 (0.52) | BDKRB1MAPK14SCN9AKDM1AHDAC1 | |
| SCHEMBL765169 | 0.85 | BDKRB1 (0.55) | BDKRB1MAPK14KDM1AHDAC1CYP3A4 | |
| SCHEMBL765822 | 0.84 | BDKRB1 (0.49) | BDKRB1MAPK14SCN9AKDM1AHDAC1 | |
| SCHEMBL764421 | 0.81 | BDKRB1 (0.43) | BDKRB1KDM1AHDAC1 | |
| SCHEMBL765837 | 0.81 | BDKRB1 (0.46) | BDKRB1MAPK14CYP3A4 | |
| SCHEMBL10121262 | 0.81 | BDKRB1 (0.44) | BDKRB1MAPK14CYP3A4 | |
| SCHEMBL12239076 | 0.79 | BDKRB1 (0.56) | BDKRB1MAPK14CYP3A4 | |
| SCHEMBL12262778 | 0.79 | BDKRB1 (0.58) | BDKRB1MAPK14HDAC1 | |
| SCHEMBL765624 | 0.79 | MAPK14 (0.53) | BDKRB1MAPK14CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188254-B1 | NOVEL BRADYKININ B1-ANTAGONISTS | BOEHRINGER INGELHEIM INT (DE) | 2012-03-21 | — | — | EP | disclosed |