SCHEMBL7658387

SCHEMBL7658387

CNC(=S)N(C)Cc1ccc(F)nc1

nearest known ligand 0.38

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.38
LMNA P02545 3/20 0.36
MEN1 O00255 1/20 0.35
ALDH1A1 P00352 1/20 0.35
HPGD P15428 1/20 0.35
KMT2A Q03164 1/20 0.35
MAPT P10636 1/20 0.35
HTT P42858 1/20 0.35
MMP2 P08253 2/20 0.35
MMP9 P14780 2/20 0.35
MMP8 P22894 2/20 0.35
MMP13 P45452 2/20 0.35
CYP11B1 P15538 1/20 0.34
CYP11B2 P19099 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.33
POLB P06746 1/20 0.33
ABCC1 P33527 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7665859 0.83 SMN1; SMN2 (0.42) SMN1; SMN2LMNAMEN1ALDH1A1HPGD
SCHEMBL7661985 0.82 ALDH1A1 (0.42) LMNAMEN1ALDH1A1KMT2AMAPT
SCHEMBL7657370 0.82 ALDH1A1 (0.41) SMN1; SMN2LMNAALDH1A1MAPTL3MBTL1
SCHEMBL7662165 0.82 SMN1; SMN2 (0.38) SMN1; SMN2LMNAMEN1ALDH1A1HPGD
SCHEMBL7657551 0.74 SMN1; SMN2 (0.62) SMN1; SMN2LMNAMEN1ALDH1A1KMT2A
SCHEMBL8064622 0.73 MMP2 (0.35) SMN1; SMN2LMNAMEN1ALDH1A1KMT2A
SCHEMBL7658385 0.72 MMP2 (0.38) LMNAMMP2MMP9MMP8MMP13
SCHEMBL7667120 0.72 POLB (0.51) SMN1; SMN2LMNAMEN1ALDH1A1HPGD
SCHEMBL7666503 0.72 SMN1; SMN2 (0.58) SMN1; SMN2LMNAMEN1ALDH1A1KMT2A
SCHEMBL11528266 0.72 CA12 (0.59) SMN1; SMN2LMNAMEN1ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6407248-B1 INSECTICIDES, MITICIDES TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2002-06-18 US disclosed
US-6124297-A COMBATTING INSECTS OR MITES TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2000-09-26 US disclosed
US-5935981-A INSECTICIDAL/MITICIDAL ACTIVITY TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-08-10 US disclosed
US-5849768-A α-unsaturated amines, their production and use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-12-15 US disclosed
EP-0529680-B1 Intermediates, their production and their use for preparing alpha-unsaturated amines TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1998-05-13 EP disclosed
EP-0302389-B1 Alpha-unsaturated amines, their production and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1993-12-22 EP disclosed
US-5214152-A Insecticides, miticides TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1993-05-25 US disclosed
EP-0529680-A2 Intermediates, their production and their use for preparing alpha-unsaturated amines TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1993-03-03 EP disclosed
US-5175301-A Insecticide, miticide, pesticide TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1992-12-29 US disclosed
EP-0509559-A2 Alpha-unsaturated amines, their production and use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1992-10-21 EP disclosed
EP-0302389-A2 Alpha-unsaturated amines, their production and use Takeda Chemical Industries, Ltd. (JP) 1989-02-08 EP disclosed