Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.47 |
| ▸ | HTR1F | P30939 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | BAZ2B | Q9UIF8 | 2/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | HTR1D | P28221 | 3/20 | 0.42 |
| ▸ | HTR1B | P28222 | 3/20 | 0.42 |
| ▸ | RB1 | P06400 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7657746 | 1.00 | SIRT1 (0.58) | SIRT1MAPTSLC6A4HTR1FHSD17B10 | |
| SCHEMBL7662514 | 1.00 | SIRT1 (0.58) | SIRT1MAPTSLC6A4HTR1FHSD17B10 | |
| Iodide SCHEMBL7660764 | 0.99 | SIRT1 (0.57) | SIRT1MAPTSLC6A4HTR1FHSD17B10 | |
| SCHEMBL6964061 | 0.89 | HTR1F (0.55) | SIRT1MAPTSLC6A4HTR1FHSD17B10 | |
| Hydrochloric Acid SCHEMBL6959661 | 0.88 | HTR1F (0.54) | SIRT1MAPTSLC6A4HTR1FHSD17B10 | |
| Iodide SCHEMBL6963382 | 0.88 | HTR1F (0.54) | SIRT1MAPTSLC6A4HTR1FHSD17B10 | |
| Iodide SCHEMBL6963386 | 0.88 | HTR1F (0.54) | SIRT1MAPTSLC6A4HTR1FHSD17B10 | |
| SCHEMBL7657750 | 0.75 | SIRT1 (0.58) | SIRT1MAPTHSD17B10BAZ2BDHODH | |
| SCHEMBL1874857 | 0.75 | SIRT1 (0.79) | SIRT1MAPTHSD17B10BAZ2BDHODH | |
| Iodide SCHEMBL7660767 | 0.74 | SIRT1 (0.57) | SIRT1MAPTHSD17B10BAZ2BDHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380201-B1 | Methods of treating or ameliorating the symptoms of common cold or allergic rhinitis with serotonin 5-HT1F agonists | ELI LILLY AND COMPANY | 2002-04-30 | — | — | US | disclosed |
| US-5962473-A | Methods of treating or ameliorating the symptoms of common cold or allergic rhinitis with serotonin 5-HT1F | ELI LILLY AND COMPANY (US) | 1999-10-05 | — | — | US | disclosed |
| US-5814653-A | SUMATRIPTAN FOR RELIEF OF MIGRAINE PAIN AND OTHER DISORDERS ASSOCIATED WITH PEPTIDE EXTRAVASATION DIE TO STUMULATION OF THE TRIGEMINAL GANGLIA; 5-HT 1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |
| EP-0832650-A2 | Use of serotonin 5-HT1F agonists for the prevention of migraine | ELI LILLY AND COMPANY (US) | 1998-04-01 | — | — | EP | disclosed |
| EP-0824917-A2 | Use of a serotonin 5-HTlf agonist in the manufacture of a medicament for treating or ameliorating the symptoms of common cold or allergic rhinitis | ELI LILLY AND COMPANY (US) | 1998-02-25 | — | — | EP | disclosed |
| US-5708187-A | MIGRANE HEADACHES | ELI LILLY AND COMPANY (US) | 1998-01-13 | — | — | US | disclosed |
| EP-0749962-A1 | 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta(7,6-B)indoles | ELI LILLY AND COMPANY (US) | 1996-12-27 | — | — | EP | disclosed |