Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 12/20 | 0.60 |
| ▸ | GRIK2 | Q13002 | 12/20 | 0.60 |
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.47 |
| ▸ | PAM | P19021 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7658433 | 1.00 | GRIK1 (0.60) | GRIK1GRIK2HTR2AGRIK3PAM | |
| SCHEMBL31030090 | 0.88 | GRIK1 (0.50) | GRIK1GRIK2HTR2AGRIK3PAM | |
| SCHEMBL1716930 | 0.82 | GRIK1 (0.65) | GRIK1GRIK2HTR2AGRIK3PAM | |
| SCHEMBL1716932 | 0.82 | GRIK1 (0.65) | GRIK1GRIK2HTR2AGRIK3PAM | |
| SCHEMBL21987028 | 0.79 | GRIK1 (0.65) | GRIK1GRIK2HTR2AGRIK3PAM | |
| SCHEMBL21987027 | 0.79 | GRIK1 (0.65) | GRIK1GRIK2HTR2AGRIK3PAM | |
| SCHEMBL3020748 | 0.78 | GRIK1 (0.59) | GRIK1GRIK2HTR2AGRIK3PAM | |
| SCHEMBL3020746 | 0.78 | GRIK1 (0.59) | GRIK1GRIK2HTR2AGRIK3PAM | |
| SCHEMBL13258634 | 0.78 | GRIK1 (0.63) | GRIK1GRIK2HTR2AGRIK3PAM | |
| SCHEMBL7005960 | 0.78 | GRIK1 (0.63) | GRIK1GRIK2HTR2AGRIK3PAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6495370-B1 | A METHOD FOR DETECTING A GLUTATHIONE-S-TRANSFERASE ISOENZYME IN A BIOLOGICAL SPECIMEN COMPRISING THE MEASUREMENT OF GLUTATHIONE-S-TRANSFERASE ENZYMATIC ACTIVITY IN THE PRESENCE AND ABSENCE AN AMOUNT OF A COMPOUND OF THE FORMULA HALO | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2002-12-17 | — | — | US | disclosed |
| US-6103665-A | Inhibition of glutathione transferase by haloenol lactones | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2000-08-15 | — | — | US | disclosed |
| US-5767147-A | MEDICAL DIAGNOSIS, TREATMENT OF DRUG RESISTANCE IN CANCER | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-06-16 | — | — | US | disclosed |
| WO-1996032936-A1 | INHIBITION OF GLUTATHIONE TRANSFERASE BY HALOENOL LACTONES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1996-10-24 | — | — | WO | disclosed |