Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 12/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 11/20 | 0.50 |
| ▸ | ITGAV | P06756 | 11/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | TLR2 | O60603 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7652514 | 0.86 | ITGB3 (0.43) | ITGB3ITGA2BITGAVHDAC3HDAC8 | |
| SCHEMBL7655271 | 0.86 | ITGB3 (0.53) | ITGB3ITGA2BITGAVJAK2JAK1 | |
| SCHEMBL7651194 | 0.78 | ITGB3 (0.74) | ITGB3ITGA2BITGAV | |
| SCHEMBL7658501 | 0.78 | ITGB3 (0.57) | ITGB3ITGA2BITGAV | |
| SCHEMBL7651416 | 0.77 | ITGB3 (0.38) | ITGB3ITGA2BITGAVTLR2HDAC3 | |
| SCHEMBL7655259 | 0.77 | ITGB3 (0.59) | ITGB3ITGA2BITGAVJAK2JAK1 | |
| SCHEMBL7658132 | 0.77 | ITGB3 (0.72) | ITGB3ITGA2BITGAV | |
| SCHEMBL7656746 | 0.75 | ITGB3 (0.73) | ITGB3ITGA2BITGAV | |
| SCHEMBL7658303 | 0.74 | ITGB3 (0.49) | ITGB3ITGA2BITGAVJAK2JAK1 | |
| SCHEMBL7653737 | 0.71 | ITGB3 (0.52) | ITGB3ITGA2BITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | claimed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | claimed |
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | disclosed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | disclosed |