Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | POLA1 | P09884 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7518675 | 0.89 | ESRRB (0.49) | P2RX7TP53POLA1HPGDPOLB | |
| SCHEMBL8081000 | 0.87 | CA1 (0.55) | P2RX7MEN1KMT2ALMNATP53 | |
| SCHEMBL7971490 | 0.85 | NPC1 (0.51) | P2RX7MEN1KMT2ALMNATP53 | |
| SCHEMBL7552476 | 0.85 | HPGD (0.54) | P2RX7MEN1KMT2AHPGDCYP1A2 | |
| SCHEMBL7560739 | 0.85 | P2RX7 (0.55) | P2RX7MEN1KMT2ALMNATP53 | |
| SCHEMBL4101685 | 0.85 | MEN1 (0.42) | P2RX7MEN1KMT2ALMNATP53 | |
| SCHEMBL5334659 | 0.84 | CYP4F2 (0.46) | P2RX7MEN1KMT2ALMNATP53 | |
| SCHEMBL7554542 | 0.84 | EPHX2 (0.49) | P2RX7MEN1KMT2ALMNATP53 | |
| SCHEMBL7560196 | 0.83 | MEN1 (0.40) | P2RX7MEN1KMT2ALMNATP53 | |
| SCHEMBL7592357 | 0.81 | HPGD (0.54) | P2RX7LMNASMN1; SMN2HPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492355-B1 | Adamantane derivatives | ASTRAZENECA AB (SE) | 2002-12-10 | — | — | US | disclosed |
| EP-1036059-A1 | ADAMANTANE DERIVATIVES | AstraZeneca UK Limited (GB) | 2000-09-20 | — | — | EP | disclosed |
| WO-1999029661-A1 | ADAMANTANE DERIVATIVES | ASTRAZENECA UK LIMITED (GB) | 1999-06-17 | — | — | WO | disclosed |