Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8081000 | 0.86 | CA1 (0.55) | MEN1KMT2ALMNATP53CA1 | |
| SCHEMBL7658512 | 0.85 | P2RX7 (0.54) | MEN1KMT2ALMNATP53SMN1; SMN2 | |
| SCHEMBL7552476 | 0.84 | HPGD (0.54) | MEN1KMT2AP2RX7HPGDCYP1A2 | |
| SCHEMBL7971490 | 0.84 | NPC1 (0.51) | MEN1KMT2ALMNATP53SMN1; SMN2 | |
| SCHEMBL7560739 | 0.84 | P2RX7 (0.55) | MEN1KMT2ALMNATP53SMN1; SMN2 | |
| SCHEMBL5334659 | 0.83 | CYP4F2 (0.46) | MEN1KMT2ALMNATP53SMN1; SMN2 | |
| SCHEMBL7554542 | 0.83 | EPHX2 (0.49) | MEN1KMT2ALMNATP53SMN1; SMN2 | |
| SCHEMBL7560196 | 0.82 | MEN1 (0.40) | MEN1KMT2ALMNATP53SMN1; SMN2 | |
| SCHEMBL7592357 | 0.80 | HPGD (0.54) | LMNASMN1; SMN2P2RX7HPGDCYP1A2 | |
| SCHEMBL6485285 | 0.80 | P2RX7 (0.53) | MEN1KMT2ALMNATP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2059497-A1 | PROCESS FOR PREPARING N-METHYLADAMANTYL DERIVATIVES BY A PALLADIUM CATALYSED COUPLING REACTION FOLLOWED BY REDUCTIVE AMINATION | AstraZeneca AB (SE) | 2009-05-20 | — | — | EP | disclosed |
| WO-2008030160-A1 | PROCESS FOR PREPARING N-METHYLADAMANTYL DERIVATIVES BY A PALLADIUM CATALYSED COUPLING REACTION FOLLOWED BY REDUCTIVE AMINATION | ASTRAZENECA AB (SE) | 2008-03-13 | — | — | WO | disclosed |