Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2527342 | 0.81 | ALDH1A1 (0.57) | ALDH1A1LMNAPOLBL3MBTL1NPC1 | |
| SCHEMBL7567992 | 0.80 | MAPT (0.47) | ALDH1A1LMNASMN1; SMN2MAPTGAA | |
| SCHEMBL25544228 | 0.80 | HSP90AA1 (0.45) | ALDH1A1LMNAL3MBTL1NPC1RAB9A | |
| SCHEMBL7562813 | 0.80 | MEN1 (0.50) | ALDH1A1LMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6697965 | 0.80 | ALDH1A1 (0.53) | ALDH1A1LMNAPOLBNPC1SMN1; SMN2 | |
| SCHEMBL7661739 | 0.79 | MAPT (0.49) | ALDH1A1SMN1; SMN2MAPTGAAKDM4E | |
| SCHEMBL7569696 | 0.79 | MAPT (0.46) | ALDH1A1SMN1; SMN2MAPTGAAKDM4E | |
| SCHEMBL7658063 | 0.79 | MAPT (0.49) | ALDH1A1L3MBTL1SMN1; SMN2MAPTGAA | |
| SCHEMBL13240461 | 0.79 | RAB9A (0.50) | ALDH1A1LMNAPOLBNPC1RAB9A | |
| SCHEMBL13280233 | 0.79 | ALDH1A1 (0.52) | ALDH1A1LMNAPOLBNPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6410539-B1 | ANTICARCINOGENIC AGENTS | ASTRAZENCA UK LIMITED (GB) | 2002-06-25 | — | — | US | disclosed |
| EP-1025089-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS FARNESYL PROTEIN TRANSFERASE INHIBITORS | ZENECA LIMITED (GB) | 2000-08-09 | — | — | EP | disclosed |
| WO-1999020612-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS FARNESYL PROTEIN TRANSFERASE INHIBITORS | ASTRAZENECA UK LIMITED (GB) | 1999-04-29 | — | — | WO | disclosed |