Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 4/20 | 0.42 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19035595 | 0.92 | LMNA (0.48) | LMNAMAPK1CA2KDM4EHIF1A | |
| SCHEMBL2105851 | 0.92 | TSHR (0.57) | TSHRALDH1A1CYP3A4HTTLMNA | |
| SCHEMBL22591738 | 0.92 | LMNA (0.48) | LMNAMAPK1CA2KDM4EHIF1A | |
| SCHEMBL18638052 | 0.92 | TSHR (0.57) | TSHRALDH1A1CYP3A4HTTLMNA | |
| SCHEMBL14977291 | 0.90 | ZDHHC7 (0.43) | TSHRHTTLMNAMAPK1POLB | |
| SCHEMBL14397158 | 0.86 | PAOX (0.39) | TSHRALDH1A1CYP3A4HTTLMNA | |
| SCHEMBL29099712 | 0.85 | ZDHHC7 (0.47) | TSHRHTTLMNAMAPK1POLB | |
| SCHEMBL29099721 | 0.85 | ZDHHC7 (0.47) | TSHRHTTLMNAMAPK1POLB | |
| SCHEMBL17485794 | 0.84 | TSHR (0.48) | TSHRALDH1A1CYP3A4HTTLMNA | |
| SCHEMBL13950295 | 0.82 | PAOX (0.39) | TSHRALDH1A1CYP3A4HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954668-B9 | HOMO- AND HETEROCYCLIC COMPOUNDS SUITABLE AS CETP INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2012-03-21 | — | — | EP | disclosed |