Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.52 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16244405 | 0.89 | LMNA (0.53) | LMNACTDSP1KDM4EAPOBEC3AAPOBEC3G | |
| SCHEMBL27603021 | 0.84 | LMNA (0.71) | LMNAKDM4ETAAR1TDP1L3MBTL1 | |
| SCHEMBL16672630 | 0.84 | CTDSP1 (0.55) | LMNACTDSP1KDM4EAPOBEC3AAPOBEC3G | |
| SCHEMBL16245538 | 0.84 | LMNA (0.71) | LMNACYP1A2KCNH2NPC1RECQL | |
| Phenprobamate SCHEMBL134496 | 0.81 | LMNA (1.00) | LMNACTDSP1KDM4EAPOBEC3AAPOBEC3G | |
| SCHEMBL21317450 | 0.81 | CTDSP1 (0.47) | LMNACTDSP1KDM4EAPOBEC3AAPOBEC3G | |
| SCHEMBL16672879 | 0.81 | CTDSP1 (0.59) | LMNACTDSP1KDM4EAPOBEC3AAPOBEC3G | |
| SCHEMBL3692999 | 0.80 | LMNA (0.66) | LMNATAAR1TDP1NR3C2NPC1 | |
| Phenprobamate SCHEMBL27286516 | 0.80 | LMNA (0.96) | LMNACTDSP1KDM4EAPOBEC3AAPOBEC3G | |
| SCHEMBL21664727 | 0.79 | KCNH2 (0.48) | LMNACTDSP1KDM4EAPOBEC3AAPOBEC3G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113164477-A | Pyrazolopyridine inhibitors of C-JUN-N-terminal kinase and uses thereof | 达纳-法伯癌症研究所股份有限公司 | 2021-07-23 | — | — | CN | disclosed |
| US-6462076-B2 | CYSTEINE PROTEASE INHIBITORS USEFUL FOR THE TREATMENT OF DISEASES ASSOCIATED WITH CYSTEINE PROTEASES, SUCH AS OSTEOPOROSIS, OSTEOARTHRITIS, RHEUMATOID ARTHRITIS, TUMOR METASTASIS, ANGINA PECTORIS, PLAQUE RUPTURE AND STROKE ETC. | HOFFMANN-LA ROCHE INC. | 2002-10-08 | — | — | US | disclosed |