Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPN1 | P15169 | 1/20 | 0.51 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.51 |
| ▸ | PPARA | Q07869 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | CPA1 | P15085 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4982285 | 0.86 | CYP2C9 (0.55) | PPARAPPARGCYP2C9CYP2C19HIF1A | |
| SCHEMBL13391309 | 0.78 | SLC6A4 (0.46) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL31381427 | 0.78 | CPN1 (0.45) | CPN1CPB2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL22765000 | 0.78 | CPN1 (0.48) | CPN1CPB2CYP2C9CYP2C19HIF1A | |
| SCHEMBL22764999 | 0.78 | CPN1 (0.48) | CPN1CPB2CYP2C9CYP2C19HIF1A | |
| SCHEMBL23751456 | 0.78 | CPN1 (0.48) | CPN1CPB2CYP2C9CYP2C19HIF1A | |
| SCHEMBL22765044 | 0.78 | CPN1 (0.48) | CPN1CPB2CYP2C9CYP2C19HIF1A | |
| SCHEMBL23751454 | 0.78 | CPN1 (0.48) | CPN1CPB2CYP2C9CYP2C19HIF1A | |
| SCHEMBL23751460 | 0.78 | CPN1 (0.48) | CPN1CPB2CYP2C9CYP2C19HIF1A | |
| SCHEMBL25963075 | 0.77 | CPN1 (0.44) | CPN1CPB2CYP2C9CYP2C19HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6444819-B1 | NEUROLEPTIC AGENTS;D4 RECEPTOR ANTAGONIST;SIDE EFFECT REDUCTION;SCHIZOPHRENIA;DRUG ABUSE, DRUG DEPENDENCE; ANXIOLYTICS; ANTIDEPRESSANTS;COGNITION ACTIVATORS. | NEUROGEN CORPORATION | 2002-09-03 | — | — | US | disclosed |
| US-20020045626-A1 | Benzylpiperazinyl and piperidinyl ethanone derivatives: dopamine receptor subtype specific ligands | NEUROGEN CORPORATION | 2002-04-18 | — | — | US | disclosed |
| US-6316470-B1 | Benzylpiperazinyl and piperidinyl ethanone derivatives: dopamine receptor subtype specific ligands | NEUROGEN CORPORATION | 2001-11-13 | — | — | US | disclosed |
| EP-1068193-A1 | BENZYLPIPERAZINYL- AND BENZYLPIPERIDINYL ETHANONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE D 4? RECEPTOR ANTAGONISTS | NEUROGEN CORPORATION (US) | 2001-01-17 | — | — | EP | disclosed |
| US-6084098-A | HIGH AFFINITY AND SELECTIVITY IN BINDING TO THE D4 RECEPTOR SUBTYPE; NEUROLEPTIC, DOPAMINERGIC AGENTS; SCHIZOPHRENIA, MANIA, COMPULSIVE BEHAVIOR, SUBSTANCE ABUSE; ANTIDEPRESSANTS; ANXIOLYTIC AGENTS; PARKINSONISM; TARDIVE DYSKINESIAS; CNS | NEUROGEN CORPORATION (US) | 2000-07-04 | — | — | US | disclosed |
| WO-1999043670-A1 | BENZYLPIPERAZINYL- AND BENZYLPIPERIDINYL ETHANONE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE D4 RECEPTOR ANTAGONISTS | NEUROGEN CORPORATION (US) | 1999-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020045626-A1 | Benzylpiperazinyl and piperidinyl ethanone derivatives: dopamine receptor subtype specific ligands | DRD2, DRD3, OPRD1 | CPN1 3880/4885CPB2 4688/4885PPARA 581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.