Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDX3X | O00571 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GCGR | P47871 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1899895 | 0.78 | NR1H2 (0.58) | DDX3XLMNANR1H2NR1H3PARP1 | |
| SCHEMBL26108539 | 0.74 | ADORA2A (0.47) | DDX3XLMNANR1H2NR1H3ADORA2A | |
| SCHEMBL27880002 | 0.73 | SMN1; SMN2 (0.56) | DDX3XLMNAMAPTALPL | |
| SCHEMBL15026752 | 0.73 | DDX3X (0.43) | DDX3XNR1H2NR1H3MAPTADORA2A | |
| SCHEMBL29109555 | 0.73 | DDX3X (0.40) | DDX3XLMNAMAPTPARP1SUCNR1 | |
| SCHEMBL31228708 | 0.72 | NR1H2 (0.50) | LMNANR1H2NR1H3ADORA2AALPL | |
| SCHEMBL26108844 | 0.72 | NR1H2 (0.50) | LMNANR1H2NR1H3ADORA2AALPL | |
| SCHEMBL7654725 | 0.71 | ROCK2 (0.53) | DDX3XMAPT | |
| SCHEMBL7661209 | 0.71 | HPGD (0.45) | DDX3XLMNAMAPTADORA3ADORA2A | |
| SCHEMBL27968243 | 0.71 | CCR1 (0.43) | DDX3XLMNANR1H2NR1H3PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6358984-B1 | FOR THERAPY OF HYPERTENSION AND/OR DISEASES SUCH AS HEART AND RENAL DISEASES | LEAD CHEMICAL CO., LTD. (JP) | 2002-03-19 | — | — | US | disclosed |
| US-6232335-B1 | A BIPHENYL TRIAZOLE COMPOUND USEFUL AS A ANGIOTENSIN II CONVERTING ENZYME INHIBITORS EFFECTIVE IN THE TREATMENT OF HYPERTENSION OR HEART FAILURE | LEAD CHEMICAL CO., LTD. (JP) | 2001-05-15 | — | — | US | disclosed |
| EP-0936221-A1 | NOVEL 2,4-DIOXOPYRROLIDINE AND 2,4-DIOXOTETRAHYDROFURAN DERIVATIVES AND MEDICINES CONTAINING THE SAME AS THE ACTIVE INGREDIENT | LEAD CHEMICAL COMPANY LTD. (JP) | 1999-08-18 | — | — | EP | disclosed |