Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 3/20 | 0.33 |
| ▸ | PHF8 | Q9UPP1 | 3/20 | 0.33 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.33 |
| ▸ | KDM4A | O75164 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HTR5A | P47898 | 2/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | HTR1D | P28221 | 1/20 | 0.30 |
| ▸ | HTR1B | P28222 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6734367 | 0.88 | PKM (0.37) | SIGMAR1SLC6A4KMT2A | |
| SCHEMBL6741613 | 0.86 | SIGMAR1 (0.40) | SIGMAR1KDM5APHF8KDM2AKDM4C | |
| SCHEMBL27538279 | 0.80 | SIGMAR1 (0.35) | SIGMAR1 | |
| SCHEMBL6898948 | 0.80 | SIGMAR1 (0.35) | SIGMAR1 | |
| SCHEMBL7214714 | 0.80 | NPC1 (0.41) | SIGMAR1MEN1KMT2ANPC1 | |
| SCHEMBL7214057 | 0.80 | NPC1 (0.41) | SIGMAR1MEN1KMT2ANPC1 | |
| SCHEMBL7214034 | 0.80 | NPC1 (0.41) | SIGMAR1MEN1KMT2ANPC1 | |
| Hydrochloric Acid SCHEMBL7220424 | 0.79 | NPC1 (0.41) | SIGMAR1MEN1KMT2ANPC1 | |
| SCHEMBL7510265 | 0.78 | SIGMAR1 (0.42) | SIGMAR1NPC1 | |
| SCHEMBL6893494 | 0.78 | KDM5A (0.35) | KDM5APHF8KDM2AKDM4CKDM4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6492370-B1 | Urea derivatives and pharmaceutical compositions thereof | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2002-12-10 | — | — | US | disclosed |