Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RB1 | P06400 | 6/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.41 |
| ▸ | HTR1F | P30939 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7662076 | 0.92 | HTR1A (0.48) | HTR1FHTR1ADRD2 | |
| SCHEMBL7666175 | 0.83 | HTR1A (0.50) | HTR1FHTR1ADRD2 | |
| SCHEMBL7659677 | 0.82 | HTR1F (0.57) | SIRT1HTR1FRORC | |
| SCHEMBL7665950 | 0.82 | HTR1F (0.57) | SIRT1HTR1FRORC | |
| SCHEMBL7653801 | 0.81 | HTR1A (0.48) | HTR1FHTR1ADRD2 | |
| SCHEMBL7204477 | 0.81 | HTR1F (0.64) | RB1HTR1FHTR1ADRD2 | |
| SCHEMBL7662511 | 0.78 | HTR1A (0.46) | HTR1FHTR1ADRD2 | |
| SCHEMBL7655526 | 0.78 | HTR1A (0.51) | HTR1FHTR1ADRD2 | |
| SCHEMBL7659301 | 0.77 | HTR1F (0.54) | HTR1FHTR1ADRD2 | |
| SCHEMBL7662072 | 0.76 | HTR1F (0.68) | HTR1FHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380201-B1 | Methods of treating or ameliorating the symptoms of common cold or allergic rhinitis with serotonin 5-HT1F agonists | ELI LILLY AND COMPANY | 2002-04-30 | — | — | US | disclosed |
| US-5962473-A | Methods of treating or ameliorating the symptoms of common cold or allergic rhinitis with serotonin 5-HT1F | ELI LILLY AND COMPANY (US) | 1999-10-05 | — | — | US | disclosed |
| US-5814653-A | SUMATRIPTAN FOR RELIEF OF MIGRAINE PAIN AND OTHER DISORDERS ASSOCIATED WITH PEPTIDE EXTRAVASATION DIE TO STUMULATION OF THE TRIGEMINAL GANGLIA; 5-HT 1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |
| EP-0832650-A2 | Use of serotonin 5-HT1F agonists for the prevention of migraine | ELI LILLY AND COMPANY (US) | 1998-04-01 | — | — | EP | disclosed |
| EP-0824917-A2 | Use of a serotonin 5-HTlf agonist in the manufacture of a medicament for treating or ameliorating the symptoms of common cold or allergic rhinitis | ELI LILLY AND COMPANY (US) | 1998-02-25 | — | — | EP | disclosed |
| US-5708187-A | MIGRANE HEADACHES | ELI LILLY AND COMPANY (US) | 1998-01-13 | — | — | US | disclosed |
| EP-0749962-A1 | 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta(7,6-B)indoles | ELI LILLY AND COMPANY (US) | 1996-12-27 | — | — | EP | disclosed |