Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 9/20 | 0.44 |
| ▸ | TACR3 | P29371 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL631125 | 0.84 | TACR3 (0.42) | PGRTACR3HTR2CAKR1B1 | |
| SCHEMBL4759006 | 0.81 | ITGB2 (0.37) | POLBTACR3PTGDR2HTR2C | |
| SCHEMBL7654525 | 0.81 | SIGMAR1 (0.40) | AKR1B1 | |
| SCHEMBL25357037 | 0.77 | POLB (0.52) | POLBPTGDR2CA12CA2CA4 | |
| SCHEMBL3839131 | 0.73 | AVPR1A (0.50) | HTR2CAKR1B1 | |
| SCHEMBL653433 | 0.72 | PGR (0.46) | PGRHTR2C | |
| SCHEMBL31122188 | 0.72 | PGR (0.46) | PGRHTR2C | |
| SCHEMBL4760203 | 0.72 | AVPR1A (0.54) | — | |
| SCHEMBL11929219 | 0.72 | POLB (0.44) | POLBPGRPTGDR2HTR2CNOTUM | |
| SCHEMBL7656937 | 0.71 | HRH1 (0.45) | PGRTACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436962-B1 | ALPHA 1A ADRENERGIC RECEPTOR ANTAGONISTS; RELIEF FROM BENIGN PROSTATIC HYPERPLASIA BY LESS HINDERED URINE FLOW BY RELAXING SMOOTH MUSCLE TISSUE; WITH A TESTOSTERONE 5-ALPHA REDUCTASE INHIBITOR, FINASTERIDE; ACUTE AND CHRONIC RELIEF | MERCK & CO., INC. | 2002-08-20 | — | — | US | disclosed |
| WO-2001022919-A2 | SPIRO[BICYCLIC -AZACYCLOALKYL AND -CYCLOALKYL] DERIVATIVES AND USES THEREOF | MERCK & CO., INC. (US) | 2001-04-05 | — | — | WO | disclosed |