Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.35 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | TYMP | P19971 | 2/20 | 0.33 |
| ▸ | ARG1 | P05089 | 1/20 | 0.33 |
| ▸ | ARG2 | P78540 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2386729 | 0.88 | ARG1 (0.40) | CYP2D6MAPTLTA4HCARM1PRMT6 | |
| SCHEMBL7655261 | 0.85 | ACHE (0.35) | CYP2D6MAPTCARM1PRMT6CHRM5 | |
| SCHEMBL772309 | 0.84 | CYP2D6 (0.47) | CYP2D6MAPTHTTLTA4HCYP3A4 | |
| SCHEMBL3431959 | 0.84 | CYP2D6 (0.47) | CYP2D6MAPTHTTLTA4HCARM1 | |
| SCHEMBL3897612 | 0.81 | CYP2D6 (0.45) | CYP2D6MAPTHTTLTA4HCARM1 | |
| SCHEMBL3431958 | 0.81 | CYP2D6 (0.45) | CYP2D6MAPTHTTLTA4HCARM1 | |
| SCHEMBL27832245 | 0.81 | CYP2D6 (0.45) | CYP2D6MAPTHTTLTA4HCARM1 | |
| SCHEMBL5066037 | 0.81 | DRD3 (0.47) | CYP2D6 | |
| SCHEMBL10064309 | 0.81 | CYP2D6 (0.45) | CYP2D6MAPTHTTLTA4HCARM1 | |
| SCHEMBL772392 | 0.81 | BCHE (0.43) | CARM1PRMT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6479507-B2 | MODULATION OF THESE INFLAMMATORY CYTOKINES IS CONSIDERED ONE OF THE MOST EFFECTIVE STRATEGIES TO BLOCK CHRONIC INFLAMMATION AND HAVE POSITIVE THERAPEUTIC OUTCOMES | SYNTEX (U.S.A.) LLC | 2002-11-12 | — | — | US | disclosed |
| US-6316464-B1 | P38 MAP kinase inhibitors | SYNTEX (U.S.A.) LLC | 2001-11-13 | — | — | US | disclosed |
| CN-1279682-A | bicyclic kinase inhibitors | HOFFMANN LA ROCHE (CH) | 2001-01-10 | — | — | CN | disclosed |