Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 6/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TYR | P14679 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.39 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.36 |
| ▸ | RARA | P10276 | 1/20 | 0.36 |
| ▸ | RARB | P10826 | 1/20 | 0.36 |
| ▸ | RARG | P13631 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7138144 | 0.84 | RXRA (0.42) | RXRAALOX5MEN1KMT2ATP53 | |
| SCHEMBL6679708 | 0.81 | RXRA (0.42) | RXRAALOX5MEN1KMT2ATP53 | |
| SCHEMBL697774 | 0.79 | RXRA (0.50) | RXRARARARARBRARG | |
| SCHEMBL8461561 | 0.79 | RXRA (0.62) | RXRARARARARBRARGPPARG | |
| SCHEMBL6678267 | 0.79 | RXRA (0.43) | RXRAALOX5MEN1KMT2ATP53 | |
| SCHEMBL8905375 | 0.77 | RXRA (0.40) | RXRAALOX5MEN1KMT2ATP53 | |
| SCHEMBL7143696 | 0.77 | RXRA (0.43) | RXRAALOX5MEN1KMT2ATP53 | |
| SCHEMBL8906033 | 0.77 | RXRA (0.40) | RXRAALOX5MEN1KMT2ATP53 | |
| SCHEMBL8905381 | 0.77 | RXRA (0.40) | RXRAALOX5MEN1KMT2ATP53 | |
| SCHEMBL6679884 | 0.77 | RXRA (0.64) | RXRARARARARBRARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403810-B2 | RESPIRATORY SYSTEM DISORDERS | HOFFMANN-LA ROCHE INC. | 2002-06-11 | — | — | US | disclosed |
| US-20020019438-A1 | Thiophene derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2002-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020019438-A1 | Thiophene derivatives | RARG, RARA, RARB | RXRA 4/4885ALOX5 998/4885MEN1 4879/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.