Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.45 |
| ▸ | HSP90B1 | P14625 | 6/20 | 0.45 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.45 |
| ▸ | KCNA3 | P22001 | 4/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.42 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7660971 | 1.00 | HSP90AA1 (0.45) | HSP90AA1HSP90B1HSP90AB1KCNA3SLC6A4 | |
| SCHEMBL7671975 | 0.90 | AGTR1 (0.49) | HSP90AA1HSP90B1KCNA3AGTR1AGTR2 | |
| SCHEMBL7671974 | 0.90 | AGTR1 (0.49) | HSP90AA1HSP90B1KCNA3AGTR1AGTR2 | |
| SCHEMBL7668237 | 0.85 | SLC6A4 (0.42) | HSP90AA1HSP90B1KCNA3SLC6A4SLC6A3 | |
| SCHEMBL7668232 | 0.85 | SLC6A4 (0.42) | HSP90AA1HSP90B1KCNA3SLC6A4SLC6A3 | |
| SCHEMBL7663134 | 0.84 | SLC6A4 (0.41) | HSP90AA1HSP90B1KCNA3SLC6A4SLC6A3 | |
| SCHEMBL7663143 | 0.84 | SLC6A4 (0.41) | HSP90AA1HSP90B1KCNA3SLC6A4SLC6A3 | |
| SCHEMBL7672485 | 0.82 | FNTA (0.50) | — | |
| SCHEMBL7672482 | 0.82 | FNTA (0.50) | — | |
| SCHEMBL7674887 | 0.76 | NAMPT (0.39) | KCNA3AGTR1AGTR2GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6486156-B1 | Chemical compounds | ASTRAZENECA AB (SE) | 2002-11-26 | — | — | US | disclosed |
| EP-1140858-A2 | ARYLPROPENYLIMIDAZOLES AS FARNESYL-PROTEIN TRANSFERASE INHIBITORS | AstraZeneca AB (SE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039716-A2 | ARYLPROPENYLIMIDAZOLES AS FARNESYL-PROTEIN TRANSFERASE INHIBITORS | ASTRAZENECA AB (SE) | 2000-07-06 | — | — | WO | disclosed |