Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.35 |
| ▸ | TUBB | P07437 | 3/20 | 0.35 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.35 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7668237 | 1.00 | SLC6A4 (0.42) | SLC6A4SLC6A3NAMPTSMN1; SMN2NPC1 | |
| SCHEMBL7674887 | 0.89 | NAMPT (0.39) | NAMPTMEN1KMT2ATUBB4ATUBB | |
| SCHEMBL7674885 | 0.89 | NAMPT (0.39) | NAMPTMEN1KMT2ATUBB4ATUBB | |
| SCHEMBL7660971 | 0.85 | HSP90AA1 (0.45) | SLC6A4SLC6A3RAB9ALMNAHSP90AA1 | |
| SCHEMBL7660976 | 0.85 | HSP90AA1 (0.45) | SLC6A4SLC6A3RAB9ALMNAHSP90AA1 | |
| SCHEMBL7663134 | 0.84 | SLC6A4 (0.41) | SLC6A4SLC6A3SMN1; SMN2NPC1CASP3 | |
| SCHEMBL7663143 | 0.84 | SLC6A4 (0.41) | SLC6A4SLC6A3SMN1; SMN2NPC1CASP3 | |
| SCHEMBL7660882 | 0.81 | SLC6A4 (0.42) | SLC6A4SLC6A3NAMPTSMN1; SMN2NPC1 | |
| SCHEMBL7660875 | 0.81 | SLC6A4 (0.42) | SLC6A4SLC6A3NAMPTSMN1; SMN2NPC1 | |
| SCHEMBL7661039 | 0.80 | SLC6A3 (0.55) | SLC6A4SLC6A3SMN1; SMN2NPC1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6486156-B1 | Chemical compounds | ASTRAZENECA AB (SE) | 2002-11-26 | — | — | US | disclosed |
| EP-1140858-A2 | ARYLPROPENYLIMIDAZOLES AS FARNESYL-PROTEIN TRANSFERASE INHIBITORS | AstraZeneca AB (SE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039716-A2 | ARYLPROPENYLIMIDAZOLES AS FARNESYL-PROTEIN TRANSFERASE INHIBITORS | ASTRAZENECA AB (SE) | 2000-07-06 | — | — | WO | disclosed |