Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM8 | O00222 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.30 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.30 |
| ▸ | BTK | Q06187 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7241989 | 0.71 | NOTUM (0.34) | GRM8GRM4NOTUMSCN8ASCN10A | |
| SCHEMBL24849937 | 0.71 | NPC1 (0.46) | NOTUMSCN8ASCN10ABTK | |
| SCHEMBL30211315 | 0.70 | NOTUM (0.39) | NOTUMBTK | |
| SCHEMBL7248539 | 0.67 | JAK2 (0.32) | SCN8ASCN10A | |
| SCHEMBL2054595 | 0.67 | NOTUM (0.42) | NOTUMSCN8ASCN10ABTK | |
| SCHEMBL5352433 | 0.64 | GAA (0.33) | NOTUMSCN8ASCN10A | |
| SCHEMBL5550999 | 0.62 | PPARA (0.52) | — | |
| SCHEMBL24943297 | 0.61 | NOTUM (0.37) | NOTUMBTK | |
| SCHEMBL31370128 | 0.60 | OPRM1 (0.39) | GRM8GRM4NOTUM | |
| SCHEMBL31370114 | 0.60 | OPRM1 (0.39) | GRM8GRM4NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436951-B1 | 3-HYDROXY-3-(4-OXO-4,6-DIHYDROINDOLIZINO (1,2-B) QUINOLINE-2-YL) PENTANOIC ACID, INHIBITING TOPOISOMERASE I AND/OR II; ANTITUMOR, PARASITICIDE; REACTING A PYRIDINONE WITH A QUINOLINE, CYCLIZATION, EPOXIDATION | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 2002-08-20 | — | — | US | disclosed |