Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.40 |
| ▸ | ITGAV | P06756 | 3/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.40 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | VDR | P11473 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7655214 | 0.89 | KDM4E (0.48) | ITGB3ITGAVITGA2BLMNAKDM4E | |
| SCHEMBL7652415 | 0.88 | KDM4E (0.44) | HSD11B1ITGB3ITGAVITGA2BKCNH2 | |
| SCHEMBL7652041 | 0.88 | KDM4E (0.44) | HSD11B1ITGB3ITGAVITGA2BKCNH2 | |
| SCHEMBL7653652 | 0.88 | KDM4E (0.44) | HSD11B1ITGB3ITGAVITGA2BKCNH2 | |
| SCHEMBL7457808 | 0.82 | ITGB3 (0.45) | ITGB3ITGAVITGA2BLMNAKDM4E | |
| SCHEMBL7464674 | 0.82 | ITGB3 (0.45) | ITGB3ITGAVITGA2BLMNAKDM4E | |
| SCHEMBL7651419 | 0.82 | ITGB3 (0.59) | ITGB3ITGAVITGA2B | |
| SCHEMBL383238 | 0.82 | ITGB3 (0.52) | ITGB3ITGAVITGA2BLMNAKDM4E | |
| SCHEMBL7654976 | 0.80 | KDM4E (0.44) | ITGB3ITGAVITGA2BLMNAKDM4E | |
| SCHEMBL7658560 | 0.80 | KDM4E (0.48) | ITGB3ITGAVITGA2BLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | claimed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | claimed |
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | disclosed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | disclosed |