Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
| ▸ | ITGAV | P06756 | 1/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7655214 | 0.91 | KDM4E (0.48) | KDM4EHTTITGB3ITGAVITGA2B | |
| SCHEMBL7658092 | 0.88 | ALDH1A1 (0.51) | KDM4EHTTITGB3ITGA2BSMN1; SMN2 | |
| SCHEMBL381838 | 0.87 | ITGB3 (0.51) | KDM4EHTTITGB3ITGAVITGA2B | |
| SCHEMBL7658795 | 0.87 | KDM4E (0.55) | KDM4EHTTITGB3ITGA2BSMN1; SMN2 | |
| SCHEMBL7463691 | 0.86 | KDM4E (0.52) | KDM4EHTTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL7654380 | 0.84 | DRD2 (0.44) | KDM4EHTTSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL7657964 | 0.84 | KDM4E (0.52) | KDM4EHTTITGB3ITGA2BSMN1; SMN2 | |
| SCHEMBL7469578 | 0.83 | ITGB3 (0.44) | KDM4EHTTITGB3ITGAVITGA2B | |
| SCHEMBL7662003 | 0.80 | HSD11B1 (0.40) | KDM4EHTTITGB3ITGAVITGA2B | |
| SCHEMBL7653683 | 0.79 | KDM4E (0.44) | KDM4EHTTITGB3ITGAVITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | claimed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | claimed |
| US-6451800-B1 | Phenylpiperazine derivatives as integrin αvβ3 antagonists | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-09-17 | — | — | US | disclosed |
| EP-1057818-A1 | PHENYLPIPERAZINE DERIVATIVES AS INTEGRIN ALPHAvBETA3 ANTAGONISTS | MEIJI SEIKA KAISHA LTD. (JP) | 2000-12-06 | — | — | EP | disclosed |