Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.73 |
| ▸ | MAPT | P10636 | 7/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.66 |
| ▸ | MEN1 | O00255 | 5/20 | 0.66 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14774709 | 0.88 | ALDH1A1 (0.85) | ALDH1A1MAPTKMT2AMEN1THRB | |
| SCHEMBL14774734 | 0.88 | ALDH1A1 (0.85) | ALDH1A1MAPTKMT2AMEN1THRB | |
| SCHEMBL28225747 | 0.85 | ALDH1A1 (0.81) | ALDH1A1MAPTKMT2AMEN1THRB | |
| SCHEMBL14774760 | 0.84 | ALDH1A1 (1.00) | ALDH1A1MAPTKMT2AMEN1THRB | |
| SCHEMBL14774773 | 0.84 | ALDH1A1 (1.00) | ALDH1A1MAPTKMT2AMEN1THRB | |
| SCHEMBL14774891 | 0.84 | ALDH1A1 (0.75) | ALDH1A1MAPTKMT2AMEN1CYP19A1 | |
| SCHEMBL14774675 | 0.84 | ALDH1A1 (0.75) | ALDH1A1MAPTKMT2AMEN1CYP19A1 | |
| SCHEMBL14774747 | 0.83 | ALDH1A1 (0.73) | ALDH1A1MAPTKMT2AMEN1CYP19A1 | |
| SCHEMBL14774616 | 0.83 | ALDH1A1 (0.73) | ALDH1A1MAPTKMT2AMEN1CYP19A1 | |
| SCHEMBL7662912 | 0.82 | ALDH1A1 (0.64) | ALDH1A1MAPTKMT2AMEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441173-B1 | NOVEL INTERMEDIATES OF AND CONVERSION TO 3-(2-(2-HYDROXYETH-1-YLOXY) OR (2-CARBOXYMETHOXY)-4-METHOXYPHENYL)-1-(3,4-METHYLENE DIOXYPHENYL)-5-(PROP-1-YLOXY)INDANE-2-CARBOXYLIC ACID | SMITHKLINE BEECHAM CORPORATION | 2002-08-27 | — | — | US | disclosed |
| US-6114549-A | Process of making 3-phenyl-1-methylenedioxyphenyl-indane-2-carboxylic acid derivatives | SMITHKLINE BEECHAM CORPORATION (US) | 2000-09-05 | — | — | US | disclosed |