Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.64 |
| ▸ | MAPT | P10636 | 6/20 | 0.59 |
| ▸ | MEN1 | O00255 | 5/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 3/20 | 0.52 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7658585 | 0.86 | ALDH1A1 (0.65) | ALDH1A1MAPTMEN1KMT2AALDH2 | |
| SCHEMBL9438991 | 0.83 | ALDH1A1 (0.66) | ALDH1A1MAPTMEN1KMT2AALDH2 | |
| SCHEMBL7662968 | 0.82 | ALDH1A1 (0.73) | ALDH1A1MAPTMEN1KMT2AALDH2 | |
| SCHEMBL18986390 | 0.81 | MAOB (0.53) | ALDH1A1MAPTMAOBHPGDTDP1 | |
| SCHEMBL14774760 | 0.79 | ALDH1A1 (1.00) | ALDH1A1MAPTMEN1KMT2AALDH2 | |
| SCHEMBL14774773 | 0.79 | ALDH1A1 (1.00) | ALDH1A1MAPTMEN1KMT2AALDH2 | |
| SCHEMBL14774734 | 0.77 | ALDH1A1 (0.85) | ALDH1A1MAPTMEN1KMT2AHPGD | |
| SCHEMBL14774709 | 0.77 | ALDH1A1 (0.85) | ALDH1A1MAPTMEN1KMT2AHPGD | |
| SCHEMBL9268118 | 0.77 | ALDH1A1 (0.48) | ALDH1A1MAPTMEN1KMT2AALDH2 | |
| SCHEMBL13194989 | 0.75 | ALDH1A1 (0.56) | ALDH1A1MAPTMEN1KMT2AALDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6441173-B1 | NOVEL INTERMEDIATES OF AND CONVERSION TO 3-(2-(2-HYDROXYETH-1-YLOXY) OR (2-CARBOXYMETHOXY)-4-METHOXYPHENYL)-1-(3,4-METHYLENE DIOXYPHENYL)-5-(PROP-1-YLOXY)INDANE-2-CARBOXYLIC ACID | SMITHKLINE BEECHAM CORPORATION | 2002-08-27 | — | — | US | disclosed |
| US-6114549-A | Process of making 3-phenyl-1-methylenedioxyphenyl-indane-2-carboxylic acid derivatives | SMITHKLINE BEECHAM CORPORATION (US) | 2000-09-05 | — | — | US | disclosed |