SCHEMBL7664103

SCHEMBL7664103

COC(=O)c1cc(COc2ccccc2)cc(-c2cccc(C(=N)N)c2)c1

nearest known ligand 0.62

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
F10 P00742 1/20 0.62
F2 P00734 11/20 0.58
MRGPRX4 Q96LA9 3/20 0.49
NR4A2 P43354 1/20 0.49
PRSS1 P07477 2/20 0.48
PRSS2 P07478 2/20 0.48
PRSS3 P35030 2/20 0.48
PLG P00747 1/20 0.47
C1S P09871 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7719048 0.94 F2 (0.66) F10F2MRGPRX4NR4A2PRSS1
SCHEMBL7668085 0.90 F2 (0.58) F10F2MRGPRX4NR4A2
SCHEMBL7658103 0.90 F2 (0.53) F10F2MRGPRX4PRSS1PRSS2
SCHEMBL7666941 0.89 F2 (0.60) F10F2MRGPRX4NR4A2PRSS1
SCHEMBL7664269 0.89 F2 (0.60) F10F2MRGPRX4PRSS1
SCHEMBL7665464 0.89 MRGPRX4 (0.54) F10F2MRGPRX4PRSS1PRSS2
SCHEMBL7668854 0.89 F2 (0.51) F10F2MRGPRX4PRSS1PRSS2
SCHEMBL7670816 0.89 F10 (0.67) F10F2MRGPRX4NR4A2PRSS1
SCHEMBL7659032 0.88 PRSS1 (0.49) F10F2PRSS1PRSS2PRSS3
SCHEMBL7660549 0.86 F2 (0.52) F10F2MRGPRX4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6348478-B1 BLOOD COAGULATION FACTORS AND ANTICOAGULANTS TEIJIN LIMITED (JP) 2002-02-19 US disclosed
EP-1043311-A1 BIPHENYLAMIDINE DERIVATIVES TEIJIN LIMITED (JP) 2000-10-11 EP disclosed