Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2D | Q13557 | 16/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7665495 | 0.98 | CAMK2D (0.41) | CAMK2DPIM1KDRGSK3BRPS6KB1 | |
| SCHEMBL7657124 | 0.97 | CAMK2D (0.39) | CAMK2DPIM1KDRGSK3B | |
| SCHEMBL7663936 | 0.96 | CAMK2D (0.39) | CAMK2DPIM1KDRGSK3B | |
| SCHEMBL7666393 | 0.90 | CAMK2D (0.36) | CAMK2DGSK3B | |
| SCHEMBL7662560 | 0.90 | PDE4B (0.40) | GSK3B | |
| SCHEMBL7653829 | 0.89 | CNR2 (0.36) | CAMK2DGSK3B | |
| SCHEMBL7657954 | 0.88 | MAOB (0.38) | KDR | |
| SCHEMBL7662842 | 0.88 | PDE4B (0.40) | GSK3B | |
| SCHEMBL7663917 | 0.88 | PDE4A (0.38) | — | |
| SCHEMBL7663926 | 0.87 | CNR1 (0.37) | KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458792-B1 | MEDICAMENT FOR THE TREATMENT OF INFLAMMATORY, IMMUNOLOGICAL, BRONCHOPULMONARY, CARDIOVASCULAR, ONCOLOGICAL OR CNS-DEGENERATIVE DISORDERS. | ASTRAZENECA AB (SE) | 2002-10-01 | — | — | US | disclosed |
| EP-1071683-A1 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2001-01-31 | — | — | EP | disclosed |
| WO-1999046264-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 1999-09-16 | — | — | WO | disclosed |