Acetic Acid

Acetic Acid

SCHEMBL7664648

CC(=O)O.NCCCn1cc(-c2nc3c(ccc4ccccc43)[nH]c2=O)c2ccc(OCc3ccccc3)cc21

nearest known ligand 0.39

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CAMK2D Q13557 5/20 0.39
TRPM8 Q7Z2W7 1/20 0.37
CNR1 P21554 1/20 0.37
CNR2 P34972 1/20 0.37
RPS6KB1 P23443 1/20 0.36
CTSV O60911 1/20 0.36
CTSL P07711 1/20 0.36
PDGFRB P09619 1/20 0.36
PDGFRA P16234 1/20 0.36
GABRA1 P14867 1/20 0.36
GABRG2 P18507 1/20 0.36
GABRB3 P28472 1/20 0.36
GABRA5 P31644 1/20 0.36
GABRA3 P34903 1/20 0.36
GABRA2 P47869 1/20 0.36
PPARG P37231 1/20 0.36
PPARD Q03181 1/20 0.36
PPARA Q07869 1/20 0.36
HRH4 Q9H3N8 1/20 0.36
KDM4E B2RXH2 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetic Acid SCHEMBL7665504 0.94 CAMK2D (0.39) CAMK2DTRPM8RPS6KB1CTSVCTSL
Acetic Acid SCHEMBL8515922 0.89 IGF1R (0.40) CAMK2DCNR1CNR2PPARGPPARD
Acetic Acid SCHEMBL7654019 0.89 EGLN1 (0.40) CAMK2DTRPM8CNR1CNR2PPARG
Acetic Acid SCHEMBL7817718 0.88 CAMK2D (0.39) CAMK2DTRPM8CNR1CNR2RPS6KB1
Acetic Acid SCHEMBL7656568 0.87 CNR1 (0.38) TRPM8CNR1CNR2GABRA1GABRG2
Acetic Acid SCHEMBL7815433 0.87 PPARG (0.40) CAMK2DTRPM8CNR1CNR2GABRA1
Acetic Acid SCHEMBL7815404 0.87 MMP13 (0.41) CAMK2DTRPM8CNR1CNR2PPARG
Acetic Acid SCHEMBL7657983 0.86 CAMK2D (0.52) CAMK2DRPS6KB1
Acetic Acid SCHEMBL7837822 0.85 CHEK1 (0.38) CAMK2DTRPM8CNR1CNR2CTSV
Acetic Acid SCHEMBL7817717 0.85 EGLN1 (0.40) CAMK2DTRPM8CNR1CNR2PPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1109799-A1 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS PACIFIC CORPORATION (KR) 2001-06-27 EP claimed
WO-2000061571-A1 4,5-DIARYL-3(2H)-FURANONE DERIVATIVES AS CYCLOOXYGENASE-2 INHIBITORS PACIFIC CORPORATION (KR) 2000-10-19 WO claimed
US-6458792-B1 MEDICAMENT FOR THE TREATMENT OF INFLAMMATORY, IMMUNOLOGICAL, BRONCHOPULMONARY, CARDIOVASCULAR, ONCOLOGICAL OR CNS-DEGENERATIVE DISORDERS. ASTRAZENECA AB (SE) 2002-10-01 US disclosed
EP-1071683-A1 NEW COMPOUNDS AstraZeneca AB (SE) 2001-01-31 EP disclosed
WO-1999046264-A1 NEW COMPOUNDS ASTRAZENECA AB (SE) 1999-09-16 WO disclosed