Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.30 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7664665 | 1.00 | KDM4E (0.33) | KDM4EHSD17B10MAPTALDH1A1USP2 | |
| SCHEMBL670912 | 0.70 | CA1 (0.45) | KDM4EHSD17B10MAPTALDH1A1USP2 | |
| SCHEMBL9692068 | 0.69 | ALDH1A1 (0.31) | MAPTALDH1A1LMNATSHR | |
| Hydrogen Sulfide SCHEMBL27764012 | 0.69 | CA1 (0.43) | KDM4EHSD17B10MAPTALDH1A1USP2 | |
| SCHEMBL10471848 | 0.65 | KMT2A (0.42) | KDM4EALDH1A1LMNAPOLBTSHR | |
| SCHEMBL10471847 | 0.65 | KMT2A (0.42) | KDM4EALDH1A1LMNAPOLBTSHR | |
| SCHEMBL9692780 | 0.65 | SLC6A2 (0.31) | MAPTALDH1A1LMNA | |
| SCHEMBL7572218 | 0.65 | DPP4 (0.35) | MAPTALDH1A1LMNA | |
| SCHEMBL873013 | 0.64 | TSHR (0.42) | KDM4EHSD17B10MAPTALDH1A1LMNA | |
| SCHEMBL8098922 | 0.62 | TSHR (0.41) | KDM4EHSD17B10MAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6355640-B1 | TREATMENT OF HYPERTENSION, UROGENITAL DISORDERS AND FORMED BY WITTIG REACTION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-03-12 | — | — | US | disclosed |
| US-5773530-A | USEFUL AS PSYCHOSTIMULANTS, ANTIHYPERTENSIVE AGENTS AND REMEDIES FOR RENAL FAILURE, DIURETICS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-06-30 | — | — | US | disclosed |
| EP-0737193-A1 | PYRAZOLOPYRIDINE ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-10-16 | — | — | EP | disclosed |
| WO-1995018128-A1 | PYRAZOLOPYRIDINE ADENOSINE ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-07-06 | — | — | WO | disclosed |