Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11192726 | 0.89 | PRMT6 (0.78) | PRMT6ALDH1A1SMN1; SMN2TDP1KDM4E | |
| SCHEMBL11339852 | 0.89 | PRMT6 (0.78) | PRMT6ALDH1A1SMN1; SMN2TDP1KDM4E | |
| SCHEMBL9839873 | 0.83 | CYP2D6 (0.57) | PRMT6ALDH1A1SMN1; SMN2TDP1KDM4E | |
| SCHEMBL9839866 | 0.82 | PRMT6 (0.55) | PRMT6ALDH1A1SMN1; SMN2TDP1KDM4E | |
| SCHEMBL10668086 | 0.81 | PRMT6 (0.62) | PRMT6ALDH1A1SMN1; SMN2TDP1KDM4E | |
| SCHEMBL20209847 | 0.80 | PRMT6 (0.66) | PRMT6ALDH1A1SMN1; SMN2TDP1KDM4E | |
| SCHEMBL111526 | 0.80 | PRMT6 (0.96) | PRMT6ALDH1A1SMN1; SMN2TDP1KDM4E | |
| SCHEMBL3742515 | 0.80 | PRMT6 (0.66) | PRMT6ALDH1A1SMN1; SMN2TDP1KDM4E | |
| SCHEMBL10849750 | 0.80 | PRMT6 (0.66) | PRMT6ALDH1A1SMN1; SMN2TDP1KDM4E | |
| SCHEMBL155081 | 0.80 | PRMT6 (0.66) | PRMT6ALDH1A1SMN1; SMN2TDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6495569-B1 | CHEMOKINE ANTAGONISTS; TREATING DISEASE ASSOCIATED WITH INFLAMMATION AND/OR PATHOGENIC LEUKOCYTE RECRUITMENT AND/OR ACTIVATION | MILLENNIUM PHARMACEUTICALS, INC. | 2002-12-17 | — | — | US | disclosed |
| WO-2002085862-A1 | IMIDAZOLIDINE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-10-31 | — | — | WO | disclosed |