Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.43 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.43 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7664667 | 0.83 | PRMT6 (0.64) | CYP2D6CYP2C9HIF1APRMT6SMN1; SMN2 | |
| SCHEMBL11192726 | 0.83 | PRMT6 (0.78) | CYP2D6CYP2C9HIF1APRMT6SMN1; SMN2 | |
| SCHEMBL11339852 | 0.83 | PRMT6 (0.78) | CYP2D6CYP2C9HIF1APRMT6SMN1; SMN2 | |
| SCHEMBL10668086 | 0.82 | PRMT6 (0.62) | CYP2D6CYP2C9HIF1APRMT6SMN1; SMN2 | |
| SCHEMBL10668832 | 0.79 | PRMT6 (0.50) | CYP2D6CYP2C9HIF1APRMT6SMN1; SMN2 | |
| SCHEMBL7813997 | 0.78 | SMN1; SMN2 (0.55) | CYP2D6CYP2C9HIF1APRMT6SMN1; SMN2 | |
| SCHEMBL9839085 | 0.78 | CXCR4 (0.49) | CYP2D6CYP2C9HIF1APRMT6SMN1; SMN2 | |
| SCHEMBL9839866 | 0.77 | PRMT6 (0.55) | CYP2D6CYP2C9HIF1APRMT6SMN1; SMN2 | |
| SCHEMBL10849750 | 0.75 | PRMT6 (0.66) | CYP2D6CYP2C9HIF1APRMT6SMN1; SMN2 | |
| SCHEMBL155081 | 0.75 | PRMT6 (0.66) | CYP2D6CYP2C9HIF1APRMT6SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0180298-B1 | PYRIMIDINE COMPOUNDS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-09-25 | — | — | EP | disclosed |
| EP-0134096-B1 | AMINOPYRIMIDINONE DERIVATIVES AS HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-02-01 | — | — | EP | disclosed |
| US-4738969-A | Substituted aminopyridones and aminoquinolones having histamine H2 -receptor blocking activity | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1988-04-19 | — | — | US | disclosed |
| US-4694008-A | HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1987-09-15 | — | — | US | disclosed |
| US-4608380-A | HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-08-26 | — | — | US | disclosed |
| EP-0180298-A2 | Pyrimidine compounds | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-05-07 | — | — | EP | disclosed |
| EP-0172968-A1 | Aminothiadiazine derivatives as histamine H2-antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-03-05 | — | — | EP | disclosed |
| US-4571398-A | Cytosine derivatives having histamine H2 -antagonist activity | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1986-02-18 | — | — | US | disclosed |
| EP-0143630-A2 | Chemical compounds | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-06-05 | — | — | EP | disclosed |
| EP-0140466-A2 | Pyrimidinone derivatives, process for their preparation, and their pharmaceutical use | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-05-08 | — | — | EP | disclosed |
| EP-0134096-A2 | Aminopyrimidinone derivatives as histamine H2-antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-03-13 | — | — | EP | disclosed |