SCHEMBL7664972

SCHEMBL7664972

O=[C]c1ccc(Cl)cc1[N+](=O)[O-]

nearest known ligand 0.71

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
VCAM1 P19320 1/20 0.71
MAPK1 P28482 3/20 0.55
TSHR P16473 1/20 0.55
ALDH1A1 P00352 4/20 0.47
L3MBTL1 Q9Y468 2/20 0.47
PDE7A Q13946 7/20 0.46
PDE7B Q9NP56 4/20 0.46
KIF18A Q8NI77 1/20 0.45
PDE4B Q07343 1/20 0.44
PDE4D Q08499 1/20 0.44
LMNA P02545 1/20 0.44
POLB P06746 1/20 0.44
NPSR1 Q6W5P4 1/20 0.42
TDP1 Q9NUW8 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8761094 0.85 MAPK1 (0.60) VCAM1MAPK1TSHRALDH1A1L3MBTL1
SCHEMBL1343562 0.83 VCAM1 (1.00) VCAM1MAPK1TSHRALDH1A1L3MBTL1
SCHEMBL13982692 0.83 VCAM1 (0.69) VCAM1MAPK1TSHRALDH1A1L3MBTL1
SCHEMBL535915 0.80 VCAM1 (0.65) VCAM1MAPK1TSHRALDH1A1L3MBTL1
SCHEMBL1795352 0.78 TDP1 (0.57) VCAM1MAPK1TSHRALDH1A1LMNA
SCHEMBL7734099 0.78 VCAM1 (0.44) VCAM1MAPK1TSHRALDH1A1POLB
SCHEMBL1524058 0.77 MAPK1 (0.72) VCAM1MAPK1TSHRALDH1A1L3MBTL1
SCHEMBL3498644 0.77 ATM (0.55) VCAM1MAPK1ALDH1A1L3MBTL1PDE7A
SCHEMBL3842281 0.77 VCAM1 (0.51) VCAM1MAPK1TSHRALDH1A1L3MBTL1
SCHEMBL29669613 0.76 VCAM1 (0.59) VCAM1MAPK1TSHRALDH1A1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6388081-B1 4-substituted-quinoline derivatives and 4-substituted-quinoline combinatorial libraries LION BIOSCIENCE AG (DE) 2002-05-14 US claimed
US-6262269-B1 4-Substituted-quinoline derivatives and 4-substituted-quinoline combinatorial libraries TREGA BIOSCIENCES, INC. 2001-07-17 US claimed
US-6143895-A TETRAHYDROQUINOLINONE COMPOUND TREGA BIOSCIENCES, INC. (US) 2000-11-07 US claimed
EP-0983507-A1 TRICYCLIC TETRAHYDROQUINOLINE DERIVATIVES AND TRICYCLIC TETRAHYDROQUINOLINE COMBINATORIAL LIBRARIES Trega Biosciences, Inc. (US) 2000-03-08 EP claimed
EP-0923734-A1 QUINOLINE DERIVATIVES AND QUINOLINE COMBINATORIAL LIBRARIES Trega Biosciences, Inc. (US) 1999-06-23 EP claimed
US-5840500-A OPIOD RECEPTORS AS ANALGESICS AND CENTRALLY ACTING PAIN KILLERS TREGA BIOSCIENCES, INC. (US) 1998-11-24 US claimed
WO-1998034111-A1 TRICYCLIC TETRAHYDROQUINOLINE DERIVATIVES AND TRICYCLIC TETRAHYDROQUINOLINE COMBINATORIAL LIBRARIES TREGA BIOSCIENCES, INC. (US) 1998-08-06 WO claimed
WO-1998002741-A9 QUINOLINE DERIVATIVES AND QUINOLINE COMBINATORIAL LIBRARIES 1998-05-22 WO claimed
WO-1998002741-A1 QUINOLINE DERIVATIVES AND QUINOLINE COMBINATORIAL LIBRARIES TREGA BIOSCIENCES, INC. (US) 1998-01-22 WO claimed
EP-3239139-B1 CHEMICAL SYNTHESIS AND ANTI-TUMOR AND ANTI-METASTATIC EFFECTS OF DUAL FUNCTIONAL CONJUGATE NINGBO COMBIREG PHARMACEUTICAL TECH CO LTD (CN) 2020-10-28 EP disclosed
EP-3239139-A1 CHEMICAL SYNTHESIS AND ANTI-TUMOR AND ANTI-METASTATIC EFFECTS OF DUAL FUNCTIONAL CONJUGATE Shenzhen Salubris Pharmaceuticals Co., Ltd (CN) 2017-11-01 EP disclosed
EP-2612857-B1 CHEMICAL SYNTHESIS AND ANTI-TUMOR AND ANTI-METASTATIC EFFECTS OF DUAL FUNCTIONAL CONJUGATE SHENZHEN SALUBRIS PHARM CO LTD (CN) 2017-07-26 EP disclosed
CN-102718775-B As the Macrocyclic quinazoline derivatives of antiproliferative JANSSEN PHARMACEUTICA N.V. (BE) 2016-02-17 CN disclosed
US-9085605-B2 Chemical synthesis and anti-tumor and anti-metastatic effects of dual functional conjugate SHENZHEN SALUBRIS PHARMACEUTICALS CO., LTD. (CN) 2015-07-21 US disclosed
WO-1998034111-A1 TRICYCLIC TETRAHYDROQUINOLINE DERIVATIVES AND TRICYCLIC TETRAHYDROQUINOLINE COMBINATORIAL LIBRARIES TREGA BIOSCIENCES, INC. (US) 1998-08-06 WO disclosed
WO-1998034115-A1 4-SUBSTITUTED-QUINOLINE DERIVATIVES AND 4-SUBSTITUTE-QUINOLINE COMBINATORIAL LIBRARIES TREGA BIOSCIENCES, INC. (US) 1998-08-06 WO disclosed
WO-1998002741-A9 QUINOLINE DERIVATIVES AND QUINOLINE COMBINATORIAL LIBRARIES 1998-05-22 WO disclosed
WO-1998002741-A1 QUINOLINE DERIVATIVES AND QUINOLINE COMBINATORIAL LIBRARIES TREGA BIOSCIENCES, INC. (US) 1998-01-22 WO disclosed
CN-1149295-A Tricyclic Dicarbonyl derivatives HOFFMANN LA ROCHE (CH) 1997-05-07 CN disclosed
EP-0278907-A1 Cyclohexane diones CIBA-GEIGY AG (CH) 1988-08-17 EP disclosed