SCHEMBL766499

SCHEMBL766499

CC(C(=O)O)n1c(N)nc2c(ncn2[C@H]2C[C@H](O)[C@@H](CO)O2)c1=O

nearest known ligand 0.56

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
PNP P00491 1/20 0.56
LMNA P02545 1/20 0.56
TP53 P04637 1/20 0.56
HTT P42858 1/20 0.56
PDE4D Q08499 1/20 0.56
PDE3A Q14432 1/20 0.56
SMN1; SMN2 Q16637 1/20 0.56
RXFP1 Q9HBX9 1/20 0.56
ADRB1 P08588 1/20 0.53
DNMT1 P26358 1/20 0.53
HIF1A Q16665 1/20 0.49
CYP1A2 P05177 1/20 0.49
HBB P68871 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3751854 0.91 PNP (0.59) PNPLMNATP53HTTPDE4D
SCHEMBL20165850 0.84 PNP (0.64) PNPLMNATP53HTTPDE4D
SCHEMBL1612645 0.84 PNP (0.56) PNPLMNATP53HTTPDE4D
SCHEMBL195449 0.84 ADORA3 (0.57) LMNAHIF1A
SCHEMBL23647921 0.83 PNP (0.62) PNPLMNATP53HTTPDE4D
SCHEMBL17521212 0.83 PNP (0.62) PNPLMNATP53HTTPDE4D
SCHEMBL7199411 0.83 PNP (0.62) PNPLMNATP53HTTPDE4D
SCHEMBL3707304 0.83 PNP (0.62) PNPLMNATP53HTTPDE4D
SCHEMBL10446997 0.82 PNP (0.64) PNPLMNATP53HTTPDE4D
SCHEMBL3744956 0.82 PNP (0.60) PNPLMNATP53HTTPDE4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11266618-B2 Methods of quantifying N2-(1-carboxyethyl)-2′-deoxy-guanosine (CEdG) and synthesis of oligonucleotides containing CEdG CITY OF HOPE (US) 2022-03-08 US claimed
US-11179361-B2 Methods of quantifying N2-(1-carboxyethyl)-2′-deoxy-guanosine (CEdG) and synthesis of oligonucleotides containing CEdG CITY OF HOPE (US) 2021-11-23 US claimed
US-20180338939-A1 METHODS OF QUANTIFYING N2-(1-CARBOXYETHYL)-2'-DEOXY-GUANOSINE (CEDG) AND SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING CEDG CITY OF HOPE 2018-11-29 US claimed
US-20180207116-A1 METHODS OF QUANTIFYING N2-(1-CARBOXYETHYL)-2'-DEOXY-GUANOSINE (CEDG) AND SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING CEDG CITY OF HOPE 2018-07-26 US claimed
US-9855233-B2 Methods of quantifying N2-(1-carboxyethyl)-2′-deoxy-guanosine (CEdG) and synthesis of oligonucleotides containing CEdG CITY OF HOPE (US) 2018-01-02 US claimed
US-20150290156-A1 METHODS OF QUANTIFYING N2-(1-CARBOXYETHYL)-2'-DEOXY-GUANOSINE (CEDG) AND SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING CEDG CITY OF HOPE 2015-10-15 US claimed
US-20120071559-A1 METHODS OF QUANTIFYING N2-(1-CARBOXYETHYL)-2'-DEOXY-GUANOSINE (CEdG) AND SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING CEdG RAHBAR SAMUEL (US) 2012-03-22 US claimed
US-20100102218-A1 METHODS OF QUANTIFYING N2-(1-CARBOXYETHYL)-2'-DEOXY-GUANOSINE (CEdG) AND SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING CEdG CITY OF HOPE 2010-04-29 US claimed
US-11835499-B2 Methods of quantifying methylglyoxal-induced nucleic acid adducts CITY OF HOPE (US) 2023-12-05 US disclosed
US-11835499-B2 Methods of quantifying methylglyoxal-induced nucleic acid adducts CITY OF HOPE (US) 2023-12-05 US disclosed
US-11266618-B2 Methods of quantifying N2-(1-carboxyethyl)-2′-deoxy-guanosine (CEdG) and synthesis of oligonucleotides containing CEdG CITY OF HOPE (US) 2022-03-08 US disclosed
US-11266618-B2 Methods of quantifying N2-(1-carboxyethyl)-2′-deoxy-guanosine (CEdG) and synthesis of oligonucleotides containing CEdG CITY OF HOPE (US) 2022-03-08 US disclosed
US-11179361-B2 Methods of quantifying N2-(1-carboxyethyl)-2′-deoxy-guanosine (CEdG) and synthesis of oligonucleotides containing CEdG CITY OF HOPE (US) 2021-11-23 US disclosed
US-11179361-B2 Methods of quantifying N2-(1-carboxyethyl)-2′-deoxy-guanosine (CEdG) and synthesis of oligonucleotides containing CEdG CITY OF HOPE (US) 2021-11-23 US disclosed
US-8277407-B2 Artificial kidney RELITECH B.V. (NL) 2012-10-02 US disclosed
US-20120071559-A1 METHODS OF QUANTIFYING N2-(1-CARBOXYETHYL)-2'-DEOXY-GUANOSINE (CEdG) AND SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING CEdG RAHBAR SAMUEL (US) 2012-03-22 US disclosed
US-20120071559-A1 METHODS OF QUANTIFYING N2-(1-CARBOXYETHYL)-2'-DEOXY-GUANOSINE (CEdG) AND SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING CEdG RAHBAR SAMUEL (US) 2012-03-22 US disclosed
US-20100185134-A1 Artifical Kidney RELITECH B.V. (NL) 2010-07-22 US disclosed
US-20100102218-A1 METHODS OF QUANTIFYING N2-(1-CARBOXYETHYL)-2'-DEOXY-GUANOSINE (CEdG) AND SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING CEdG CITY OF HOPE 2010-04-29 US disclosed
US-20100102218-A1 METHODS OF QUANTIFYING N2-(1-CARBOXYETHYL)-2'-DEOXY-GUANOSINE (CEdG) AND SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING CEdG CITY OF HOPE 2010-04-29 US disclosed